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Characteristics and Treatment Outcomes of Isoniazid Mono-Resistant Tuberculosis: A Retrospective Study

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dc.contributor.author강영애-
dc.contributor.author김송이-
dc.contributor.author김영삼-
dc.contributor.author김은영-
dc.contributor.author박무석-
dc.contributor.author이상훈-
dc.contributor.author이수환-
dc.contributor.author이은혜-
dc.contributor.author임아영-
dc.contributor.author장준-
dc.contributor.author정경수-
dc.contributor.author정지예-
dc.contributor.author최지수-
dc.contributor.author곽세현-
dc.date.accessioned2021-05-21T16:45:42Z-
dc.date.available2021-05-21T16:45:42Z-
dc.date.issued2020-12-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182553-
dc.description.abstractPurpose: Isoniazid (INH) mono-resistant tuberculosis (Hr-TB) is a highly prevalent type of drug-resistant TB, possibly associated with unfavorable treatment outcomes. However, definitive guidelines on an optimal treatment regimen and duration for Hr-TB are currently under discussion. We evaluated the characteristics and treatment outcomes of Hr-TB patients. Materials and methods: We retrospectively reviewed the medical records of Hr-TB patients treated at a South Korean tertiary referral hospital from January 2005 to December 2018. Results: We included 195 Hr-TB patients. 113 (57.9%) were male, and the median age was 56.6 [interquartile range, 40.2-68.6] years. Mutations in katG were the most frequent [54 (56.3%)], followed by those in the inhA [34 (35.4%)]. Favorable and unfavorable outcomes were noted in 164 (84.1%) and 31 (15.9%) patients, respectively. Smoking history [odds ratio (OR)=5.606, 95% confidence interval (CI): 1.695-18.543, p=0.005], low albumin level (OR=0.246, 95% CI: 0.104-0.578, p=0.001), and positive acid-fast bacilli culture at 2 months (OR=7.853, 95% CI: 1.246-49.506, p=0.028) were associated with unfavorable outcomes. Conclusion: A tailored strategy targeting high-risk patients is imperative for improved treatment outcomes. Further research on the rapid and accurate detection of resistance to INH and other companion drugs is warranted.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntitubercular Agents / pharmacology-
dc.subject.MESHAntitubercular Agents / therapeutic use*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIsoniazid / pharmacology-
dc.subject.MESHIsoniazid / therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation-
dc.subject.MESHMycobacterium tuberculosis / drug effects-
dc.subject.MESHMycobacterium tuberculosis / genetics-
dc.subject.MESHMycobacterium tuberculosis / isolation & purification*-
dc.subject.MESHPrevalence-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTuberculosis / drug therapy-
dc.subject.MESHTuberculosis, Multidrug-Resistant / drug therapy*-
dc.titleCharacteristics and Treatment Outcomes of Isoniazid Mono-Resistant Tuberculosis: A Retrospective Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSe Hyun Kwak-
dc.contributor.googleauthorJi Soo Choi-
dc.contributor.googleauthorEun Hye Lee-
dc.contributor.googleauthorSu Hwan Lee-
dc.contributor.googleauthorAh Young Leem-
dc.contributor.googleauthorSang Hoon Lee-
dc.contributor.googleauthorSong Yee Kim-
dc.contributor.googleauthorKyung Soo Chung-
dc.contributor.googleauthorEun Young Kim-
dc.contributor.googleauthorJi Ye Jung-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorJoon Chang-
dc.contributor.googleauthorYoung Ae Kang-
dc.identifier.doi10.3349/ymj.2020.61.12.1034-
dc.contributor.localIdA00057-
dc.contributor.localIdA00626-
dc.contributor.localIdA00707-
dc.contributor.localIdA00811-
dc.contributor.localIdA01457-
dc.contributor.localIdA02836-
dc.contributor.localIdA02904-
dc.contributor.localIdA03053-
dc.contributor.localIdA03382-
dc.contributor.localIdA03472-
dc.contributor.localIdA03570-
dc.contributor.localIdA03735-
dc.contributor.localIdA05057-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid33251777-
dc.subject.keywordTuberculosis-
dc.subject.keywordisoniazid-
dc.subject.keywordtreatment outcome-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.affiliatedAuthor강영애-
dc.contributor.affiliatedAuthor김송이-
dc.contributor.affiliatedAuthor김영삼-
dc.contributor.affiliatedAuthor김은영-
dc.contributor.affiliatedAuthor박무석-
dc.contributor.affiliatedAuthor이상훈-
dc.contributor.affiliatedAuthor이수환-
dc.contributor.affiliatedAuthor이은혜-
dc.contributor.affiliatedAuthor임아영-
dc.contributor.affiliatedAuthor장준-
dc.contributor.affiliatedAuthor정경수-
dc.contributor.affiliatedAuthor정지예-
dc.contributor.affiliatedAuthor최지수-
dc.citation.volume61-
dc.citation.number12-
dc.citation.startPage1034-
dc.citation.endPage1041-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.61(12) : 1034-1041, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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