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Risk factors of COVID-19 mortality: a systematic review of current literature and lessons from recent retracted articles

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dc.contributor.author신재일-
dc.contributor.author이금화-
dc.date.accessioned2021-05-21T16:44:51Z-
dc.date.available2021-05-21T16:44:51Z-
dc.date.issued2020-12-
dc.identifier.issn1128-3602-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182548-
dc.description.abstractObjective: Recently, two influential articles that reported the association of (hydroxy)chloroquine or angiotensin converting enzyme (ACE) inhibitors and coronavirus disease 2019 (COVID-19) mortality were retracted due to significant methodological issues. Therefore, we aimed to analyze the same clinical issues through an improved research method and to find out the differences from the retracted papers. We systematically reviewed pre-existing literature, and compared the results with those of the retracted papers to gain a novel insight. Materials and methods: We extracted common risk factors identified in two retracted papers, and conducted relevant publication search until June 26, 2020 in PubMed. Then, we analyzed the risk factors for COVID-19 mortality and compared them to those of the retracted papers. Results: Our systematic review demonstrated that most demographic and clinical risk factors for COVID-19 mortality were similar to those of the retracted papers. However, while the retracted paper indicated that both (hydroxy)chloroquine monotherapy and combination therapy with macrolide were associated with higher risk of mortality, our study showed that only combination therapy of hydroxychloroquine and macrolide was associated with higher risk of mortality (odds ratio 2.33; 95% confidence interval 1.63-3.34). In addition, our study demonstrated that use of ACE inhibitors or angiotensin receptor blockers (ARBs) was associated with reduced risk of mortality (0.77; 0.65-0.91). Conclusions: When analyzing the same clinical issues with the two retracted papers through a systematic review of randomized controlled trials and relevant cohort studies, we found out that (hydroxy)chloroquine monotherapy was not associated with higher risk of mortality, and that the use of ACE inhibitors or ARBs was associated with reduced risk of mortality in COVID-19 patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherVerduci-
dc.relation.isPartOfEUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAfrican Continental Ancestry Group / statistics & numerical data-
dc.subject.MESHAge Factors-
dc.subject.MESHAngiotensin Receptor Antagonists / therapeutic use*-
dc.subject.MESHAngiotensin-Converting Enzyme Inhibitors / therapeutic use*-
dc.subject.MESHAsian Continental Ancestry Group / statistics & numerical data-
dc.subject.MESHCOVID-19 / drug therapy-
dc.subject.MESHCOVID-19 / epidemiology-
dc.subject.MESHCOVID-19 / immunology-
dc.subject.MESHCOVID-19 / mortality*-
dc.subject.MESHCoronary Artery Disease / epidemiology-
dc.subject.MESHDatabases, Factual-
dc.subject.MESHDiabetes Mellitus / epidemiology-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHEnzyme Inhibitors / therapeutic use*-
dc.subject.MESHHeart Failure / epidemiology-
dc.subject.MESHHumans-
dc.subject.MESHHydroxychloroquine / therapeutic use*-
dc.subject.MESHHypertension / epidemiology-
dc.subject.MESHImmunocompromised Host / immunology-
dc.subject.MESHInformation Dissemination-
dc.subject.MESHMacrolides / therapeutic use-
dc.subject.MESHObesity / epidemiology-
dc.subject.MESHOrgan Dysfunction Scores-
dc.subject.MESHProtective Factors-
dc.subject.MESHPulmonary Disease, Chronic Obstructive / epidemiology-
dc.subject.MESHRandomized Controlled Trials as Topic-
dc.subject.MESHRetraction of Publication as Topic*-
dc.subject.MESHRisk Factors-
dc.subject.MESHSARS-CoV-2-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSex Factors-
dc.subject.MESHSmoking / epidemiology-
dc.titleRisk factors of COVID-19 mortality: a systematic review of current literature and lessons from recent retracted articles-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.department;Dept. of Pediatrics (소아과학교실)-
dc.contributor.googleauthorK H Lee-
dc.contributor.googleauthorJ S Kim-
dc.contributor.googleauthorS H Hong-
dc.contributor.googleauthorD Seong-
dc.contributor.googleauthorY R Choi-
dc.contributor.googleauthorY T Ahn-
dc.contributor.googleauthorK S Kim-
dc.contributor.googleauthorS E Kim-
dc.contributor.googleauthorS Lee-
dc.contributor.googleauthorW Sim-
dc.contributor.googleauthorD Kim-
dc.contributor.googleauthorB Jun-
dc.contributor.googleauthorJ W Yang-
dc.contributor.googleauthorD K Yon-
dc.contributor.googleauthorS W Lee-
dc.contributor.googleauthorM S Kim-
dc.contributor.googleauthorE Dragioti-
dc.contributor.googleauthorH Li-
dc.contributor.googleauthorL Jacob-
dc.contributor.googleauthorA Koyanagi-
dc.contributor.googleauthorR Abou Ghayda-
dc.contributor.googleauthorJ I Shin-
dc.contributor.googleauthorL Smith-
dc.identifier.doi10.26355/eurrev_202012_24216-
dc.contributor.localIdA02142-
dc.contributor.localIdA04622-
dc.relation.journalcodeJ03872-
dc.identifier.eissn2284-0729-
dc.identifier.pmid33378062-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.affiliatedAuthor신재일-
dc.contributor.affiliatedAuthor이금화-
dc.citation.volume24-
dc.citation.number24-
dc.citation.startPage13089-
dc.citation.endPage13097-
dc.identifier.bibliographicCitationEUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, Vol.24(24) : 13089-13097, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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