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Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | 라선영 | - |
dc.date.accessioned | 2021-05-21T16:41:48Z | - |
dc.date.available | 2021-05-21T16:41:48Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182524 | - |
dc.description.abstract | Epstein-Barr virus (EBV) is associated with several human malignancies including 8-10% of gastric cancers (GCs). Genome-wide analysis of 3D chromatin topologies across GC lines, primary tissue and normal gastric samples revealed chromatin domains specific to EBV-positive GC, exhibiting heterochromatin-to-euchromatin transitions and long-range human-viral interactions with non-integrated EBV episomes. EBV infection in vitro suffices to remodel chromatin topology and function at EBV-interacting host genomic loci, converting H3K9me3+ heterochromatin to H3K4me1+/H3K27ac+ bivalency and unleashing latent enhancers to engage and activate nearby GC-related genes (for example TGFBR2 and MZT1). Higher-order epigenotypes of EBV-positive GC thus signify a novel oncogenic paradigm whereby non-integrative viral genomes can directly alter host epigenetic landscapes ('enhancer infestation'), facilitating proto-oncogene activation and tumorigenesis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Nature Pub. Co. | - |
dc.relation.isPartOf | NATURE GENETICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adenocarcinoma / genetics* | - |
dc.subject.MESH | Adenocarcinoma / virology* | - |
dc.subject.MESH | Carcinogenesis / genetics | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Chromatin / genetics* | - |
dc.subject.MESH | Epigenomics / methods | - |
dc.subject.MESH | Epstein-Barr Virus Infections / genetics* | - |
dc.subject.MESH | Herpesvirus 4, Human / genetics* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Stomach Neoplasms / genetics* | - |
dc.subject.MESH | Stomach Neoplasms / virology* | - |
dc.subject.MESH | Transcription, Genetic / genetics* | - |
dc.title | Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Atsushi Okabe | - |
dc.contributor.googleauthor | Kie Kyon Huang | - |
dc.contributor.googleauthor | Keisuke Matsusaka | - |
dc.contributor.googleauthor | Masaki Fukuyo | - |
dc.contributor.googleauthor | Manjie Xing 3 | - |
dc.contributor.googleauthor | Xuewen Ong | - |
dc.contributor.googleauthor | Takayuki Hoshii | - |
dc.contributor.googleauthor | Genki Usui | - |
dc.contributor.googleauthor | Motoaki Seki | - |
dc.contributor.googleauthor | Yasunobu Mano | - |
dc.contributor.googleauthor | Bahityar Rahmutulla | - |
dc.contributor.googleauthor | Teru Kanda | - |
dc.contributor.googleauthor | Takayoshi Suzuki | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Tetsuo Ushiku | - |
dc.contributor.googleauthor | Masashi Fukayama | - |
dc.contributor.googleauthor | Patrick Tan | - |
dc.contributor.googleauthor | Atsushi Kaneda | - |
dc.identifier.doi | 10.1038/s41588-020-0665-7 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J02294 | - |
dc.identifier.eissn | 1546-1718 | - |
dc.identifier.pmid | 32719515 | - |
dc.identifier.url | https://www.nature.com/articles/s41588-020-0665-7 | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.affiliatedAuthor | 라선영 | - |
dc.citation.volume | 52 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 919 | - |
dc.citation.endPage | 930 | - |
dc.identifier.bibliographicCitation | NATURE GENETICS, Vol.52(9) : 919-930, 2020-09 | - |
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