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Effects of bisphosphonates on long-term kidney transplantation outcomes

DC FieldValueLanguage
dc.contributor.author김명수-
dc.contributor.author김범석-
dc.contributor.author김순일-
dc.contributor.author김유선-
dc.contributor.author김하얀-
dc.contributor.author남정모-
dc.contributor.author정현주-
dc.contributor.author최훈영-
dc.contributor.author허규하-
dc.date.accessioned2021-04-29T17:40:16Z-
dc.date.available2021-04-29T17:40:16Z-
dc.date.issued2021-03-
dc.identifier.issn0931-0509-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182462-
dc.description.abstractBackground: Bisphosphonates are administered to post-transplantation patients with mineral and bone disorders; however, the association between bisphosphonate therapy and long-term renal graft survival remains unclear. Methods: This nested case-control study investigated the effects of bisphosphonates on long-term graft outcomes after kidney transplantation. We enrolled 3836 kidney transplant recipients treated from April 1979 to June 2016 and matched patients with graft failure to those without (controls). Annual post-transplant bone mineral density assessments were performed and recipients with osteopenia or osteoporosis received bisphosphonate therapy. The associations between bisphosphonate use and long-term graft outcomes and graft survival were analyzed using conditional logistic regression and landmark analyses, respectively. Results: A landmark analysis demonstrated that death-censored graft survival was significantly higher in bisphosphonate users than in non-users in the entire cohort (log-rank test, P < 0.001). In the nested case-control matched cohort, bisphosphonate users had a significantly reduced risk of graft failure than did non-users (odds ratio = 0.38; 95% confidence interval 0.30-0.48). Bisphosphonate use, increased cumulative duration of bisphosphonate use >1 year and increased cumulative bisphosphonate dose above the first quartile were associated with a reduced risk of graft failure, after adjustments. Conclusions: Bisphosphonates may improve long-term graft survival in kidney transplant recipients.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfNEPHROLOGY DIALYSIS TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffects of bisphosphonates on long-term kidney transplantation outcomes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorSeung Hwan Song-
dc.contributor.googleauthorHoon Young Choi-
dc.contributor.googleauthorHa Yan Kim-
dc.contributor.googleauthorChung Mo Nam-
dc.contributor.googleauthorHyeon Joo Jeong-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorSoon I I Kim-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorKyu Ha Huh-
dc.contributor.googleauthorBeom Seok Kim-
dc.identifier.doi10.1093/ndt/gfaa371-
dc.contributor.localIdA00424-
dc.contributor.localIdA00488-
dc.contributor.localIdA00649-
dc.contributor.localIdA00785-
dc.contributor.localIdA01091-
dc.contributor.localIdA01264-
dc.contributor.localIdA03771-
dc.contributor.localIdA04226-
dc.contributor.localIdA04344-
dc.relation.journalcodeJ02316-
dc.identifier.eissn1460-2385-
dc.identifier.pmid33367861-
dc.identifier.urlhttps://academic.oup.com/ndt/article/36/4/722/6047010-
dc.subject.keywordbisphosphonates-
dc.subject.keywordgraft outcomes-
dc.subject.keywordgraft survival-
dc.subject.keywordkidney transplant-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.affiliatedAuthor김명수-
dc.contributor.affiliatedAuthor김범석-
dc.contributor.affiliatedAuthor김순일-
dc.contributor.affiliatedAuthor김유선-
dc.contributor.affiliatedAuthor김하얀-
dc.contributor.affiliatedAuthor남정모-
dc.contributor.affiliatedAuthor정현주-
dc.contributor.affiliatedAuthor최훈영-
dc.contributor.affiliatedAuthor허규하-
dc.citation.volume36-
dc.citation.number4-
dc.citation.startPage722-
dc.citation.endPage729-
dc.identifier.bibliographicCitationNEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.36(4) : 722-729, 2021-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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