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Biologic behavior of resected BRCA-mutated pancreatic cancer: Comparison with sporadic pancreatic cancer and other BRCA-related cancers
DC Field | Value | Language |
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dc.contributor.author | 강창무 | - |
dc.contributor.author | 김성현 | - |
dc.contributor.author | 이우정 | - |
dc.contributor.author | 황호경 | - |
dc.date.accessioned | 2021-04-29T17:39:10Z | - |
dc.date.available | 2021-04-29T17:39:10Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 1424-3903 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182452 | - |
dc.description.abstract | Background: Since margin-negative resection is essential for the cure of pancreatic cancer (PC), early detection of PC is important. Although PC is the third most common cancer associated with BRCA1/2 mutations, clinical research regarding BRCA mutations in resected PC are rare. In this study, we investigated the oncologic characteristics of resected PC with BRCA mutation to suggest management strategies. Methods: We retrospectively reviewed data from 493 patients who were confirmed to be pathogenic BRCA1/2 mutation carriers between January 2007 and December 2019. We investigated the oncologic characteristics of PC patients by comparing them with resected sporadic PC and other BRCA-related cancer groups (breast cancer, ovarian cancer, and others). Results: Ten BRCA mutation carriers (2.0%) experienced PC, and PC onset was significantly later than that of BRCA-related breast cancer (age: breast vs. pancreas, 45.0 vs. 53.5 years, p = 0.050). Six patients underwent pancreatectomy and their long-term survival outcomes did not differ from those of sporadic PC patients (disease free survival: BRCA1/2 vs. sporadic, 10.0 months vs. 9.0 months, p = 0.504; overall survival: BRCA1/2 vs. sporadic, 29.0 months vs. 35.0 months, p = 0.520). Conclusion: BRCA-mutated PC occurs later than BRCA-mutated breast cancer. Active genetic testing to identify BRCA1/2 mutation carriers at the onset of breast cancer and continuous long-term surveillance of these patients can provide opportunities to detect BRCA-mutated PC at a resectable stage. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier India | - |
dc.relation.isPartOf | PANCREATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Biologic behavior of resected BRCA-mutated pancreatic cancer: Comparison with sporadic pancreatic cancer and other BRCA-related cancers | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Sung Hyun Kim | - |
dc.contributor.googleauthor | Ho Kyoung Hwang | - |
dc.contributor.googleauthor | Woo Jung Lee | - |
dc.contributor.googleauthor | Chang Moo Kang | - |
dc.identifier.doi | 10.1016/j.pan.2021.02.007 | - |
dc.contributor.localId | A00088 | - |
dc.contributor.localId | A04529 | - |
dc.contributor.localId | A02993 | - |
dc.contributor.localId | A04497 | - |
dc.relation.journalcode | J02464 | - |
dc.identifier.eissn | 1424-3911 | - |
dc.identifier.pmid | 33612442 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1424390321000570 | - |
dc.subject.keyword | BRCA | - |
dc.subject.keyword | Breast neopla는 | - |
dc.subject.keyword | Early diagnosis | - |
dc.subject.keyword | Genetic testing | - |
dc.subject.keyword | Pancreatic neoplasms | - |
dc.subject.keyword | Surveillance | - |
dc.contributor.alternativeName | Kang, Chang Moo | - |
dc.contributor.affiliatedAuthor | 강창무 | - |
dc.contributor.affiliatedAuthor | 김성현 | - |
dc.contributor.affiliatedAuthor | 이우정 | - |
dc.contributor.affiliatedAuthor | 황호경 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 544 | - |
dc.citation.endPage | 549 | - |
dc.identifier.bibliographicCitation | PANCREATOLOGY, Vol.21(3) : 544-549, 2021-04 | - |
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