Cited 37 times in
Gut microbiota-derived metabolite trimethylamine N-oxide as a biomarker in early Parkinson's disease
DC Field | Value | Language |
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dc.contributor.author | 손영호 | - |
dc.contributor.author | 예병석 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 이상국 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 정석종 | - |
dc.contributor.author | 백경원 | - |
dc.contributor.author | 유한수 | - |
dc.date.accessioned | 2021-04-29T17:26:04Z | - |
dc.date.available | 2021-04-29T17:26:04Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 0899-9007 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182338 | - |
dc.description.abstract | Objectives: This study aimed to investigate the potential of using changes in the plasma levels of trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, as a biomarker in early Parkinson's disease (PD). Methods: Plasma TMAO levels were measured in 85 patients with drug-naïve early stage PD and 20 healthy controls. A linear mixed model was used to assess longitudinal changes in levodopa-equivalent dose (LED) during follow-up (>2 y) in three tertile PD groups according to plasma TMAO levels. Additionally, a Cox regression analysis was performed to assess the effect of plasma TMAO levels on dementia conversion. Results: Plasma TMAO levels of patients with PD were lower than those of healthy controls. A linear mixed model demonstrated that patients with PD and lower levels of TMAO (<4.75 μmol/L; i.e., lowest tertile group) exhibited faster increases in LED over time. The Cox regression model did not reveal that plasma TMAO level was associated with the risk for dementia conversion (P = 0.488). However, when we divided patients with PD into two subgroups according to bet cutoff TMAO level to maximize the log-rank statistics, the PD group with a low plasma TMAO level (<6.92 μmol/L) had a higher risk (with borderline statistical significance) for PD-dementia conversion than the group with a high TMAO level (hazard ratio: 7.565; 95% confidence interval, 1.004-57.019; P = 0.050). Conclusions: The results demonstrate that lower baseline plasma TMAO levels are associated with faster increases in LED and tend to increase the risk for PD-dementia conversion, suggesting the prognostic implications of TMAO in early stage PD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | NUTRITION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Gut microbiota-derived metabolite trimethylamine N-oxide as a biomarker in early Parkinson's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Seok Jong Chung | - |
dc.contributor.googleauthor | John Hoon Rim | - |
dc.contributor.googleauthor | Dajeong Ji | - |
dc.contributor.googleauthor | Sangwon Lee | - |
dc.contributor.googleauthor | Han Soo Yoo | - |
dc.contributor.googleauthor | Jin Ho Jung | - |
dc.contributor.googleauthor | KyoungWon Baik | - |
dc.contributor.googleauthor | Yonghoon Choi | - |
dc.contributor.googleauthor | Byoung Seok Ye | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Sang-Guk Lee | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.identifier.doi | 10.1016/j.nut.2020.111090 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A04603 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A02810 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A04666 | - |
dc.relation.journalcode | J02397 | - |
dc.identifier.eissn | 1873-1244 | - |
dc.identifier.pmid | 33418492 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0899900720303737 | - |
dc.subject.keyword | Dementia | - |
dc.subject.keyword | Gut microbiota | - |
dc.subject.keyword | Parkinson's disease | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Trimethylamine N-oxide (TMAO) | - |
dc.contributor.alternativeName | Sohn, Young Ho | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.contributor.affiliatedAuthor | 예병석 | - |
dc.contributor.affiliatedAuthor | 윤미진 | - |
dc.contributor.affiliatedAuthor | 이상국 | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.citation.volume | 83 | - |
dc.citation.startPage | 111090 | - |
dc.identifier.bibliographicCitation | NUTRITION, Vol.83 : 111090, 2021-03 | - |
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