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Peripheral natural killer cell activity is associated with poor clinical outcomes in pancreatic ductal adenocarcinoma

DC FieldValueLanguage
dc.contributor.author강화평-
dc.contributor.author박승우-
dc.contributor.author박정엽-
dc.contributor.author방승민-
dc.contributor.author송시영-
dc.contributor.author이희승-
dc.contributor.author임가람-
dc.contributor.author정문재-
dc.contributor.author조중현-
dc.date.accessioned2021-04-29T17:25:13Z-
dc.date.available2021-04-29T17:25:13Z-
dc.date.issued2021-02-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182332-
dc.description.abstractBackground and aim: We aimed to measure the natural killer (NK) cell activity and pro-inflammatory cytokine levels in the peripheral blood of pancreatic cancer patients and investigate the correlation of NK cell activity and cytokines with cancer status and clinical outcomes. Methods: We prospectively enrolled patients who were pathologically diagnosed with pancreatic ductal adenocarcinoma (PDAC) between 2016 and 2017 at a tertiary hospital in Seoul, South Korea. As a control group, healthy participants were enrolled by mobile application recruitment. Results: A total of 203 patients were enrolled for this study (PDAC, n = 102; healthy participants, n = 101). The peripheral blood NK cell activity of PDAC patients was significantly lower than that of healthy participants (median level, 95 pg/mL vs 2000 pg/mL, P < 0.001), and decreased NK cell activity was correlated to poor clinical outcome in terms of response to chemotherapy, tumor progression, and survival. The pro-inflammatory cytokine interleukin-6 had a strong negative correlation with NK cell activity. Conclusions: In pancreatic cancer patients, NK cell activity decreased as cancer progressed, and decreased NK cell activity was associated with poor clinical outcomes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Scientific Publications-
dc.relation.isPartOfJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePeripheral natural killer cell activity is associated with poor clinical outcomes in pancreatic ductal adenocarcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHee Seung Lee-
dc.contributor.googleauthorGalam Leem-
dc.contributor.googleauthorHuapyong Kang-
dc.contributor.googleauthorJung Hyun Jo-
dc.contributor.googleauthorMoon Jae Chung-
dc.contributor.googleauthorSoo Jeong Jang-
dc.contributor.googleauthorDa Hae Yoon-
dc.contributor.googleauthorJeong Youp Park-
dc.contributor.googleauthorSeung Woo Park-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorSeungmin Bang-
dc.identifier.doi10.1111/jgh.15265-
dc.contributor.localIdA00100-
dc.contributor.localIdA01551-
dc.contributor.localIdA01647-
dc.contributor.localIdA01786-
dc.contributor.localIdA02035-
dc.contributor.localIdA03349-
dc.contributor.localIdA06055-
dc.contributor.localIdA03602-
dc.contributor.localIdA03912-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid32969514-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/jgh.15265-
dc.subject.keywordBiliary neoplasms-
dc.subject.keywordInnate immunity-
dc.subject.keywordPancreatic cancer-
dc.contributor.alternativeNameKang, Huapyong-
dc.contributor.affiliatedAuthor강화평-
dc.contributor.affiliatedAuthor박승우-
dc.contributor.affiliatedAuthor박정엽-
dc.contributor.affiliatedAuthor방승민-
dc.contributor.affiliatedAuthor송시영-
dc.contributor.affiliatedAuthor이희승-
dc.contributor.affiliatedAuthor임가람-
dc.contributor.affiliatedAuthor정문재-
dc.contributor.affiliatedAuthor조중현-
dc.citation.volume36-
dc.citation.number2-
dc.citation.startPage516-
dc.citation.endPage522-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.36(2) : 516-522, 2021-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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