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Radiotherapy as an immune checkpoint blockade combination strategy for hepatocellular carcinoma

Authors
 Byung Min Lee  ;  Jinsil Seong 
Citation
 WORLD JOURNAL OF GASTROENTEROLOGY, Vol.27(10) : 919-927, 2021-03 
Journal Title
 WORLD JOURNAL OF GASTROENTEROLOGY 
ISSN
 1007-9327 
Issue Date
2021-03
Keywords
Hepatocellular carcinoma ; Immune checkpoint inhibitor ; Immune modulation ; Immune oncology ; Radiotherapy ; Tumor microenvironment
Abstract
In the immune oncology era, the clinical efficacy of immune checkpoint inhibitors (ICIs) against most solid cancers is well known. In hepatocellular carcinoma, the recent success of combination therapy with targeting agents has accelerated the search for novel combination strategies. Radiotherapy (RT), an attractive modality, can be combined with ICIs, which act as strong modulators of the tumor immune microenvironment. Herein, we discuss immune modulation caused by radiation and the current trials of RT-ICI combination treatment as well as future perspectives.
Files in This Item:
T202101020.pdf Download
DOI
10.3748/wjg.v27.i10.919
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Lee, Byung Min(이병민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182331
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