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Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging

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dc.contributor.author석정호-
dc.date.accessioned2021-04-29T17:20:12Z-
dc.date.available2021-04-29T17:20:12Z-
dc.date.issued2021-03-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182291-
dc.description.abstractEarly life stress (ELS) is strongly associated with psychiatric disorders such as anxiety, depression, and schizophrenia in adulthood. To date, biological, behavioral, and structural aspects of ELS have been studied extensively, but their functional effects remain unclear. Here, we examined NeuroPET studies of dopaminergic, glutamatergic, and serotonergic systems in ELS animal models. Maternal separation and restraint stress were used to generate single or complex developmental trauma. Body weights of animals exposed to single trauma were similar to those of control animals; however, animals exposed to complex trauma exhibited loss of body weight when compared to controls. In behavioral tests, the complex developmental trauma group exhibited a decrease in time spent in the open arm of the elevated plus-maze and an increase in immobility time in the forced swim test when compared to control animals. In NeuroPET studies, the complex trauma group displayed a reduction in brain uptake values when compared to single trauma and control groups. Of neurotransmitter systems analyzed, the rate of decrease in brain uptake was the highest in the serotonergic group. Collectively, our results indicate that developmental trauma events induce behavioral deficits, including anxiety- and depressive-like phenotypes and dysfunction in neurotransmitter systems.-
dc.description.statementOfResponsibilityopen-
dc.languageINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.publisherINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEvaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학교실)-
dc.contributor.googleauthorNamhun Lee-
dc.contributor.googleauthorSe-Jong Oh-
dc.contributor.googleauthorJang-Woo Park-
dc.contributor.googleauthorKyung-Rok Nam-
dc.contributor.googleauthorKyung-Jun Kang-
dc.contributor.googleauthorKyo-Chul Lee-
dc.contributor.googleauthorYong-Jin Lee-
dc.contributor.googleauthorJune-Seek Choi-
dc.contributor.googleauthorJeong-Ho Seok-
dc.contributor.googleauthorJae-Yong Choi-
dc.identifier.doi10.3390/ijms22052522-
dc.contributor.localIdA01929-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid33802338-
dc.subject.keywordearly life stress-
dc.subject.keywordneurotransmission-
dc.subject.keywordpositron emission tomography-
dc.subject.keywordtrauma-
dc.contributor.alternativeNameSeok, Jeong Ho-
dc.contributor.affiliatedAuthor석정호-
dc.citation.volume22-
dc.citation.number5-
dc.citation.startPage2522-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(5) : 2522, 2021-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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