Cited 5 times in
Nogo-A regulates myogenesis via interacting with Filamin-C
DC Field | Value | Language |
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dc.contributor.author | 최영철 | - |
dc.date.accessioned | 2021-04-29T17:18:08Z | - |
dc.date.available | 2021-04-29T17:18:08Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182272 | - |
dc.description.abstract | Among the three isoforms encoded by Rtn4, Nogo-A has been intensely investigated as a central nervous system inhibitor. Although Nogo-A expression is increased in muscles of patients with amyotrophic lateral sclerosis, its role in muscle homeostasis and regeneration is not well elucidated. In this study, we discovered a significant increase in Nogo-A expression in various muscle-related pathological conditions. Nogo-/- mice displayed dystrophic muscle structure, dysregulated muscle regeneration following injury, and altered gene expression involving lipid storage and muscle cell differentiation. We hypothesized that increased Nogo-A levels might regulate muscle regeneration. Differentiating myoblasts exhibited Nogo-A upregulation and silencing Nogo-A abrogated myoblast differentiation. Nogo-A interacted with filamin-C, suggesting a role for Nogo-A in cytoskeletal arrangement during myogenesis. In conclusion, Nogo-A maintains muscle homeostasis and integrity, and pathologically altered Nogo-A expression mediates muscle regeneration, suggesting Nogo-A as a novel target for the treatment of myopathies in clinical settings. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | CELL DEATH DISCOVERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Nogo-A regulates myogenesis via interacting with Filamin-C | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | SunYoung Park | - |
dc.contributor.googleauthor | Ji-Hwan Park | - |
dc.contributor.googleauthor | Un-Beom Kang | - |
dc.contributor.googleauthor | Seong-Kyoon Choi | - |
dc.contributor.googleauthor | Ahmed Elfadl | - |
dc.contributor.googleauthor | H M Arif Ullah | - |
dc.contributor.googleauthor | Myung-Jin Chung | - |
dc.contributor.googleauthor | Ji-Yoon Son | - |
dc.contributor.googleauthor | Hyun Ho Yun | - |
dc.contributor.googleauthor | Jae-Min Park | - |
dc.contributor.googleauthor | Jae-Hyuk Yim | - |
dc.contributor.googleauthor | Seung-Jun Jung | - |
dc.contributor.googleauthor | Sang-Hyup Kim | - |
dc.contributor.googleauthor | Young-Chul Choi | - |
dc.contributor.googleauthor | Dae-Seong Kim | - |
dc.contributor.googleauthor | Jin-Hong Shin | - |
dc.contributor.googleauthor | Jin-Sung Park | - |
dc.contributor.googleauthor | Keun Hur | - |
dc.contributor.googleauthor | Sang-Han Lee | - |
dc.contributor.googleauthor | Eun-Joo Lee | - |
dc.contributor.googleauthor | Daehee Hwang | - |
dc.contributor.googleauthor | Kyu-Shik Jeong | - |
dc.identifier.doi | 10.1038/s41420-020-00384-x | - |
dc.contributor.localId | A04116 | - |
dc.relation.journalcode | J03612 | - |
dc.identifier.eissn | 2058-7716 | - |
dc.identifier.pmid | 33414425 | - |
dc.contributor.alternativeName | Choi, Young Chul | - |
dc.contributor.affiliatedAuthor | 최영철 | - |
dc.citation.volume | 7 | - |
dc.citation.startPage | 1 | - |
dc.identifier.bibliographicCitation | CELL DEATH DISCOVERY, Vol.7 : 1, 2021-01 | - |
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