Cited 63 times in
Obesity and the risk of primary liver cancer: A systematic review and meta-analysis
DC Field | Value | Language |
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dc.contributor.author | 이현웅 | - |
dc.contributor.author | 임진홍 | - |
dc.date.accessioned | 2021-04-29T17:15:38Z | - |
dc.date.available | 2021-04-29T17:15:38Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 2287-2728 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182250 | - |
dc.description.abstract | Background/aims: In this systematic review and meta-analysis, we aimed to clarify the effect of obesity on the occurrence of and mortality from primary liver cancer. Methods: This study was conducted using a systematic literature search of MEDLINE, EMBASE, and the Cochrane Library until November 2018 using the primary keywords "obesity," "overweight," "body mass index (BMI)," "body weight," "liver," "cancer," "hepatocellular carcinoma," "liver cancer," "risk," and "mortality." Studies assessing the relationship between BMI and occurrence of or mortality from primary liver cancer in prospective cohorts and those reporting hazard ratios (HRs) or data that allow HR estimation were included. Results: A total of 28 prospective cohort studies with 8,135,906 subjects were included in the final analysis. These included 22 studies with 6,059,561 subjects for cancer occurrence and seven studies with 2,077,425 subjects for cancerrelated mortality. In the meta-analysis, an increase in BMI was associated with the occurrence of primary liver cancer (HR, 1.69; 95% confidence interval, 1.50-1.90, I2=56%). A BMI-dependent increase in the risk of occurrence of primary liver cancer was reported. HRs were 1.36 (95% CI, 1.02-1.81), 1.77 (95% CI, 1.56-2.01), and 3.08 (95% CI, 1.21-7.86) for BMI >25 kg/m2, >30 kg/m2, and >35 kg/m2, respectively. Furthermore, increased BMI resulted in enhanced liver cancer-related mortality (HR, 1.61; 95% CI, 1.14-2.27, I2=80%). Conclusion: High BMI increases liver cancer mortality and occurrence of primary liver cancer. Obesity is an independent risk factor for the occurrence of and mortality from primary liver cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Association for the Study of the Liver | - |
dc.relation.isPartOf | CLINICAL AND MOLECULAR HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Obesity and the risk of primary liver cancer: A systematic review and meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Won Sohn | - |
dc.contributor.googleauthor | Hyun Woong Lee | - |
dc.contributor.googleauthor | Sangheun Lee | - |
dc.contributor.googleauthor | Jin Hong Lim | - |
dc.contributor.googleauthor | Min Woo Lee | - |
dc.contributor.googleauthor | Chan Hyuk Park | - |
dc.contributor.googleauthor | Seung Kew Yoon | - |
dc.identifier.doi | 10.3350/cmh.2020.0176 | - |
dc.contributor.localId | A03292 | - |
dc.contributor.localId | A03411 | - |
dc.relation.journalcode | J00557 | - |
dc.identifier.eissn | 2287-285X | - |
dc.identifier.pmid | 33238333 | - |
dc.subject.keyword | Carcinoma, Hepatocellular | - |
dc.subject.keyword | Liver cancer | - |
dc.subject.keyword | Mortality | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | Risk | - |
dc.contributor.alternativeName | Lee, Hyun Woong | - |
dc.contributor.affiliatedAuthor | 이현웅 | - |
dc.contributor.affiliatedAuthor | 임진홍 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 157 | - |
dc.citation.endPage | 174 | - |
dc.identifier.bibliographicCitation | CLINICAL AND MOLECULAR HEPATOLOGY, Vol.27(1) : 157-174, 2021-01 | - |
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