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Fluconazole-Resistant Candida glabrata Bloodstream Isolates, South Korea, 2008-2018

DC FieldValueLanguage
dc.contributor.author용동은-
dc.date.accessioned2021-04-29T17:10:52Z-
dc.date.available2021-04-29T17:10:52Z-
dc.date.issued2021-03-
dc.identifier.issn1080-6040-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182219-
dc.description.abstractWe investigated the clinical outcomes and molecular mechanisms of fluconazole-resistant (FR) Candida glabrata bloodstream infections. Among 1,158 isolates collected during multicenter studies in South Korea during 2008–2018, 5.7% were FR. For 64 patients with FR bloodstream infection isolates, the 30-day mortality rate was 60.9% and the 90-day mortality rate 78.2%; these rates were significantly higher than in patients with fluconazole-susceptible dose-dependent isolates (30-day mortality rate 36.4%, 90-day mortality rate 43.8%; p<0.05). For patients with FR isolates, appropriate antifungal therapy was the only independent protective factor associated with 30-day (hazard ratio 0.304) and 90-day (hazard ratio 0.310) mortality. Sequencing of pleiotropic drug-resistance transcription factor revealed that 1–2 additional Pdr1p amino acid substitutions (except genotype-specific Pdr1p amino acid substitutions) occurred in 98.5% of FR isolates but in only 0.9% of fluconazole-susceptible dose-dependent isolates. These results highlight the high mortality rate of patients infected with FR C. glabrata BSI isolates harboring Pdr1p mutations.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNational Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC)-
dc.relation.isPartOfEMERGING INFECTIOUS DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleFluconazole-Resistant Candida glabrata Bloodstream Isolates, South Korea, 2008-2018-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.googleauthorEun Jeong Won-
dc.contributor.googleauthorMin Ji Choi-
dc.contributor.googleauthorMi-Na Kim-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorWee Gyo Lee-
dc.contributor.googleauthorYoung Uh-
dc.contributor.googleauthorTaek Soo Kim-
dc.contributor.googleauthorSeung Ah Byeon-
dc.contributor.googleauthorSeung Yeob Lee-
dc.contributor.googleauthorSoo Hyun Kim-
dc.contributor.googleauthorJong Hee Shin-
dc.identifier.doi10.3201/eid2703.203482-
dc.contributor.localIdA02423-
dc.relation.journalcodeJ00767-
dc.identifier.eissn1080-6059-
dc.identifier.pmid33624581-
dc.subject.keywordCandida glabrata-
dc.subject.keywordPDR1-
dc.subject.keywordSouth Korea-
dc.subject.keywordantimicrobial resistance-
dc.subject.keywordcandidemia-
dc.subject.keywordfluconazole resistance-
dc.subject.keywordfungal infections-
dc.subject.keywordfungi-
dc.subject.keywordmortality-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.affiliatedAuthor용동은-
dc.citation.volume27-
dc.citation.number3-
dc.citation.startPage779-
dc.citation.endPage788-
dc.identifier.bibliographicCitationEMERGING INFECTIOUS DISEASES, Vol.27(3) : 779-788, 2021-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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