Cited 14 times in
Fluconazole-Resistant Candida glabrata Bloodstream Isolates, South Korea, 2008-2018
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.date.accessioned | 2021-04-29T17:10:52Z | - |
dc.date.available | 2021-04-29T17:10:52Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 1080-6040 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182219 | - |
dc.description.abstract | We investigated the clinical outcomes and molecular mechanisms of fluconazole-resistant (FR) Candida glabrata bloodstream infections. Among 1,158 isolates collected during multicenter studies in South Korea during 2008–2018, 5.7% were FR. For 64 patients with FR bloodstream infection isolates, the 30-day mortality rate was 60.9% and the 90-day mortality rate 78.2%; these rates were significantly higher than in patients with fluconazole-susceptible dose-dependent isolates (30-day mortality rate 36.4%, 90-day mortality rate 43.8%; p<0.05). For patients with FR isolates, appropriate antifungal therapy was the only independent protective factor associated with 30-day (hazard ratio 0.304) and 90-day (hazard ratio 0.310) mortality. Sequencing of pleiotropic drug-resistance transcription factor revealed that 1–2 additional Pdr1p amino acid substitutions (except genotype-specific Pdr1p amino acid substitutions) occurred in 98.5% of FR isolates but in only 0.9% of fluconazole-susceptible dose-dependent isolates. These results highlight the high mortality rate of patients infected with FR C. glabrata BSI isolates harboring Pdr1p mutations. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) | - |
dc.relation.isPartOf | EMERGING INFECTIOUS DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Fluconazole-Resistant Candida glabrata Bloodstream Isolates, South Korea, 2008-2018 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Eun Jeong Won | - |
dc.contributor.googleauthor | Min Ji Choi | - |
dc.contributor.googleauthor | Mi-Na Kim | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Wee Gyo Lee | - |
dc.contributor.googleauthor | Young Uh | - |
dc.contributor.googleauthor | Taek Soo Kim | - |
dc.contributor.googleauthor | Seung Ah Byeon | - |
dc.contributor.googleauthor | Seung Yeob Lee | - |
dc.contributor.googleauthor | Soo Hyun Kim | - |
dc.contributor.googleauthor | Jong Hee Shin | - |
dc.identifier.doi | 10.3201/eid2703.203482 | - |
dc.contributor.localId | A02423 | - |
dc.relation.journalcode | J00767 | - |
dc.identifier.eissn | 1080-6059 | - |
dc.identifier.pmid | 33624581 | - |
dc.subject.keyword | Candida glabrata | - |
dc.subject.keyword | PDR1 | - |
dc.subject.keyword | South Korea | - |
dc.subject.keyword | antimicrobial resistance | - |
dc.subject.keyword | candidemia | - |
dc.subject.keyword | fluconazole resistance | - |
dc.subject.keyword | fungal infections | - |
dc.subject.keyword | fungi | - |
dc.subject.keyword | mortality | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | 용동은 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 779 | - |
dc.citation.endPage | 788 | - |
dc.identifier.bibliographicCitation | EMERGING INFECTIOUS DISEASES, Vol.27(3) : 779-788, 2021-03 | - |
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