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Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver

DC Field Value Language
dc.contributor.author남기택-
dc.date.accessioned2021-04-29T17:08:41Z-
dc.date.available2021-04-29T17:08:41Z-
dc.date.issued2021-02-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182204-
dc.description.abstractIonizable lipid nanoparticles (LNPs) have been widely used for in vivo delivery of RNA therapeutics into the liver. However, a main challenge remains to develop LNP formulations for selective delivery of RNA into certain types of liver cells, such as hepatocytes and liver sinusoidal endothelial cells (LSECs). Here, we report the engineered LNPs for the targeted delivery of RNA into hepatocytes and LSECs. The effects of particle size and polyethylene glycol-lipid content in the LNPs were evaluated for the hepatocyte-specific delivery of mRNA by ApoE-mediated cellular uptake through low-density lipoprotein receptors. Targeted delivery of RNA to LSECs was further investigated using active ligands. Incorporation of mannose allowed the selective delivery of RNA to LSECs, while minimizing the unwanted cellular uptake by hepatocytes. These results demonstrate that engineered LNPs have great potential for the cell type-specific delivery of RNA into the liver and other tissues.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Association for the Advancement of Science-
dc.relation.isPartOfSCIENCE ADVANCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEngineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorM Kim-
dc.contributor.googleauthorM Jeong-
dc.contributor.googleauthorS Hur-
dc.contributor.googleauthorY Cho-
dc.contributor.googleauthorJ Park-
dc.contributor.googleauthorH Jung-
dc.contributor.googleauthorY Seo-
dc.contributor.googleauthorH A Woo-
dc.contributor.googleauthorK T Nam-
dc.contributor.googleauthorK Lee-
dc.contributor.googleauthorH Lee-
dc.identifier.doi10.1126/sciadv.abf4398-
dc.contributor.localIdA01243-
dc.relation.journalcodeJ03735-
dc.identifier.eissn2375-2548-
dc.identifier.pmid33637537-
dc.contributor.alternativeNameNam, Ki Taek-
dc.contributor.affiliatedAuthor남기택-
dc.citation.volume7-
dc.citation.number9-
dc.citation.startPageeabf4398-
dc.identifier.bibliographicCitationSCIENCE ADVANCES, Vol.7(9) : eabf4398, 2021-02-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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