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O- Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity

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dc.contributor.author이용호-
dc.date.accessioned2021-04-29T17:06:19Z-
dc.date.available2021-04-29T17:06:19Z-
dc.date.issued2021-02-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182182-
dc.description.abstractPost-translational modifications, including O-GlcNAcylation, play fundamental roles in modulating cellular events, including transcription, signal transduction, and immune signaling. Several molecular targets of O-GlcNAcylation associated with pathogen-induced innate immune responses have been identified; however, the direct regulatory mechanisms linking O-GlcNAcylation with antiviral RIG-I-like receptor signaling are not fully understood. In this study, we found that cellular levels of O-GlcNAcylation decline in response to infection with Sendai virus. We identified a heavily O-GlcNAcylated serine-rich region between amino acids 249-257 of the mitochondrial antiviral signaling protein (MAVS); modification at this site disrupts MAVS aggregation and prevents MAVS-mediated activation and signaling. O-GlcNAcylation of the serine-rich region of MAVS also suppresses its interaction with TRAF3; this prevents IRF3 activation and production of interferon-β. Taken together, these results suggest that O-GlcNAcylation of MAVS may be a master regulatory event that promotes host defense against RNA viruses.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleO- Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJunghwa Seo-
dc.contributor.googleauthorYun Soo Park-
dc.contributor.googleauthorTae Hyun Kweon-
dc.contributor.googleauthorJingu Kang-
dc.contributor.googleauthorSeongjin Son-
dc.contributor.googleauthorHan Byeol Kim-
dc.contributor.googleauthorYu Ri Seo-
dc.contributor.googleauthorMin Jueng Kang-
dc.contributor.googleauthorEugene C Yi-
dc.contributor.googleauthorYong-Ho Lee-
dc.contributor.googleauthorJin-Hong Kim-
dc.contributor.googleauthorBoyoun Park-
dc.contributor.googleauthorWon Ho Yang-
dc.contributor.googleauthorJin Won Cho-
dc.identifier.doi10.3389/fimmu.2020.589259-
dc.contributor.localIdA02989-
dc.relation.journalcodeJ03075-
dc.identifier.eissn1664-3224-
dc.identifier.pmid33603735-
dc.subject.keywordO-linked N-Acetylglucosamine (O-GlcNAc)-
dc.subject.keywordRIG-I-like receptors signaling-
dc.subject.keywordhost defense mechanism-
dc.subject.keywordinnate immunity-
dc.subject.keywordmitochondrial antiviral signaling protein-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.affiliatedAuthor이용호-
dc.citation.volume11-
dc.citation.startPage589259-
dc.identifier.bibliographicCitationFRONTIERS IN IMMUNOLOGY, Vol.11 : 589259, 2021-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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