Cited 3 times in
O- Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이용호 | - |
dc.date.accessioned | 2021-04-29T17:06:19Z | - |
dc.date.available | 2021-04-29T17:06:19Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182182 | - |
dc.description.abstract | Post-translational modifications, including O-GlcNAcylation, play fundamental roles in modulating cellular events, including transcription, signal transduction, and immune signaling. Several molecular targets of O-GlcNAcylation associated with pathogen-induced innate immune responses have been identified; however, the direct regulatory mechanisms linking O-GlcNAcylation with antiviral RIG-I-like receptor signaling are not fully understood. In this study, we found that cellular levels of O-GlcNAcylation decline in response to infection with Sendai virus. We identified a heavily O-GlcNAcylated serine-rich region between amino acids 249-257 of the mitochondrial antiviral signaling protein (MAVS); modification at this site disrupts MAVS aggregation and prevents MAVS-mediated activation and signaling. O-GlcNAcylation of the serine-rich region of MAVS also suppresses its interaction with TRAF3; this prevents IRF3 activation and production of interferon-β. Taken together, these results suggest that O-GlcNAcylation of MAVS may be a master regulatory event that promotes host defense against RNA viruses. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | O- Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Junghwa Seo | - |
dc.contributor.googleauthor | Yun Soo Park | - |
dc.contributor.googleauthor | Tae Hyun Kweon | - |
dc.contributor.googleauthor | Jingu Kang | - |
dc.contributor.googleauthor | Seongjin Son | - |
dc.contributor.googleauthor | Han Byeol Kim | - |
dc.contributor.googleauthor | Yu Ri Seo | - |
dc.contributor.googleauthor | Min Jueng Kang | - |
dc.contributor.googleauthor | Eugene C Yi | - |
dc.contributor.googleauthor | Yong-Ho Lee | - |
dc.contributor.googleauthor | Jin-Hong Kim | - |
dc.contributor.googleauthor | Boyoun Park | - |
dc.contributor.googleauthor | Won Ho Yang | - |
dc.contributor.googleauthor | Jin Won Cho | - |
dc.identifier.doi | 10.3389/fimmu.2020.589259 | - |
dc.contributor.localId | A02989 | - |
dc.relation.journalcode | J03075 | - |
dc.identifier.eissn | 1664-3224 | - |
dc.identifier.pmid | 33603735 | - |
dc.subject.keyword | O-linked N-Acetylglucosamine (O-GlcNAc) | - |
dc.subject.keyword | RIG-I-like receptors signaling | - |
dc.subject.keyword | host defense mechanism | - |
dc.subject.keyword | innate immunity | - |
dc.subject.keyword | mitochondrial antiviral signaling protein | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | 이용호 | - |
dc.citation.volume | 11 | - |
dc.citation.startPage | 589259 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN IMMUNOLOGY, Vol.11 : 589259, 2021-02 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.