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Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers

DC FieldValueLanguage
dc.contributor.author김지현-
dc.contributor.author박재준-
dc.contributor.author박준철-
dc.contributor.author박효진-
dc.contributor.author신성관-
dc.contributor.author윤영훈-
dc.contributor.author이상길-
dc.contributor.author이용찬-
dc.contributor.author정다현-
dc.date.accessioned2021-04-29T17:02:23Z-
dc.date.available2021-04-29T17:02:23Z-
dc.date.issued2021-03-
dc.identifier.issn0192-0790-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182151-
dc.description.abstractGoals: We assessed the efficacy of polaprezinc plus proton pump inhibitor (PPI) treatment for endoscopic submucosal dissection (ESD)-induced ulcer healing compared with rebamipide plus PPI treatment. Background: ESD has been widely used as a local treatment option that cures gastric neoplasms. However, it causes large and deep artificial ulcers, and there are no guidelines with regard to the optimal treatment durations and drug regimens for ESD-induced ulcers. Polaprezinc is effective for promoting ulcer healing and helps enhance the quality of ulcer healing. Study: Two hundred ten patients with ESD-induced ulcers were randomly allocated to treatment with polaprezinc (150 mg/d) plus pantoprazole (40 mg/d) or treatment with rebamipide (300 mg/d) plus pantoprazole (40 mg/d). We evaluated the ulcer healing rate and condition of the ulcer at 4 weeks after dissection. The χ2 or Fisher exact test and the Student t test were used. Results: The ulcer healing rates at 4 weeks after dissection in the polaprezinc plus pantoprazole treatment group were not inferior compared with those in the rebamipide plus pantoprazole treatment group, both in the intention-to-treat analysis (90.3% and 91.4%, respectively, P=0.523) and per-protocol analysis (89.9% and 91.1%, respectively, P=0.531). The short procedure time was an independent predictive factor for a high ulcer healing rate (odds ratio: 0.975; 95% confidence interval: 0.958-0.993; P=0.006). Conclusion: The polaprezinc plus PPI treatment showed noninferiority to rebamipide plus PPI treatment in the ulcer healing rate at 4 weeks after ESD.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWolters Kluwer Health, Inc.-
dc.relation.isPartOfJOURNAL OF CLINICAL GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleComparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorDa Hyun Jung-
dc.contributor.googleauthorJun Chul Park-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorSang Kil Lee-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorHyunsoo Chung-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorJie-Hyun Kim-
dc.contributor.googleauthorYoung Hoon Youn-
dc.contributor.googleauthorHyojin Park-
dc.identifier.doi10.1097/MCG.0000000000001357-
dc.contributor.localIdA00996-
dc.contributor.localIdA01636-
dc.contributor.localIdA01676-
dc.contributor.localIdA01774-
dc.contributor.localIdA02112-
dc.contributor.localIdA02583-
dc.contributor.localIdA02812-
dc.contributor.localIdA02988-
dc.contributor.localIdA03591-
dc.relation.journalcodeJ01319-
dc.identifier.eissn1539-2031-
dc.identifier.pmid32341237-
dc.contributor.alternativeNameKim, Jie-Hyun-
dc.contributor.affiliatedAuthor김지현-
dc.contributor.affiliatedAuthor박재준-
dc.contributor.affiliatedAuthor박준철-
dc.contributor.affiliatedAuthor박효진-
dc.contributor.affiliatedAuthor신성관-
dc.contributor.affiliatedAuthor윤영훈-
dc.contributor.affiliatedAuthor이상길-
dc.contributor.affiliatedAuthor이용찬-
dc.contributor.affiliatedAuthor정다현-
dc.citation.volume55-
dc.citation.number3-
dc.citation.startPage233-
dc.citation.endPage238-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL GASTROENTEROLOGY, Vol.55(3) : 233-238, 2021-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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