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Impact of Dyslipidemia on the Risk of Second Cancer in Thyroid Cancer Patients: A Korean National Cohort Study

Authors
 Joon Ho  ;  Eunhwa Kim  ;  Minkyung Han  ;  Inkyung Jung  ;  Jandee Lee  ;  Young Suk Jo 
Citation
 ANNALS OF SURGICAL ONCOLOGY, : epub., 2021-01 
Journal Title
 ANNALS OF SURGICAL ONCOLOGY 
ISSN
 1068-9265 
Issue Date
2021-01
Abstract
Background: Studies have shown that radioactive iodine therapy (RAIT) affects the development of second cancer in thyroid cancer patients. The impact of other factors, such as dyslipidemia are not clear. Methods: A retrospective analysis of thyroid cancer patients with a 1,251,913 person-year follow-up was conducted using data from the Health Insurance Review and Assessment database in South Korea from January 2008 to December 2018. We investigated factors related to second cancer development using a nested case-control analysis to avoid length bias. Results: The overall risk of developing second cancer was higher in thyroid cancer patients than in the general population [standardized incidence ratio, 3.34; 95% confidence interval (CI) 3.30-3.39]. Second cancer incidence was higher in patients who received RAIT than in those who did not [odds ratio (OR) 1.130; 95% CI 1.094-1.169]. Moreover, the risk of second cancer was higher in patients with dyslipidemia than in those without dyslipidemia (OR 1.265; 95% CI 1.223-1.309). After adjustment for RAIT, the incidence of a second cancer was higher in patients with dyslipidemia than in those without dyslipidemia (OR 1.262; 95% CI 1.221-1.306). Conclusions: The risk of second cancer development in patients with thyroid cancer appears to be high. Dyslipidemia may be associated with an increased risk of several types of second cancers.
Full Text
https://link.springer.com/article/10.1245%2Fs10434-020-09570-8
DOI
10.1245/s10434-020-09570-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jan Dee(이잔디) ORCID logo https://orcid.org/0000-0003-4090-0049
Jung, Inkyung(정인경) ORCID logo https://orcid.org/0000-0003-3780-3213
Jo, Young Suk(조영석) ORCID logo https://orcid.org/0000-0001-9926-8389
Han, Minkyung(한민경) ORCID logo https://orcid.org/0000-0002-5011-5557
Ho, Joon(허준)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182120
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