Cited 41 times in
Co-delivery of curcumin and miRNA-144-3p using heart-targeted extracellular vesicles enhances the therapeutic efficacy for myocardial infarction
DC Field | Value | Language |
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dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2021-04-29T16:56:32Z | - |
dc.date.available | 2021-04-29T16:56:32Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182099 | - |
dc.description.abstract | Curcumin exerts therapeutic effects in heart disease, but has limited bioavailability. Extracellular vesicles (EVs) have gained attention as nanovehicles; however, the poor targeting ability of systemically administered EVs still remains a crucial issue. Herein, we generated heart-targeted EVs (CTP-EVs) by functionalizing EVs surface with cardiac targeting peptide (CTP) using genetic modification of EVs-secreting cells, and further loaded curcumin into CTP-EVs (CTP-EVs-Cur). Consequently, CTP-EVs were able to specifically deliver curcumin to the heart. In addition, curcumin-loaded CTP-EVs possess improved bioavailability, and are fully functional with a high cardioprotective efficiency. Moreover, we loaded miR-144-3p in CTP-EVs-Cur following validation of miR-144-3p as a major contributor in curcumin-mediated therapeutic effects. The simultaneous packing of curcumin and miR-144-3p in CTP-EVs not only retains the active heart-targeting ability but also achieves enhanced cardioprotective effects both in vitro and in vivo, indicating the possibility of combining and sustaining their therapeutic potential by simultaneously loading in CTP-EVs. Therefore, CTP-EVs could be a potential and effective strategy for the delivery of therapeutic molecules, thereby providing a promising nanomedicine for MI therapy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Publishers | - |
dc.relation.isPartOf | JOURNAL OF CONTROLLED RELEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Co-delivery of curcumin and miRNA-144-3p using heart-targeted extracellular vesicles enhances the therapeutic efficacy for myocardial infarction | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ji-Young Kang | - |
dc.contributor.googleauthor | Hyoeun Kim | - |
dc.contributor.googleauthor | Dasom Mun | - |
dc.contributor.googleauthor | Nuri Yun | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.identifier.doi | 10.1016/j.jconrel.2021.01.018 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J01352 | - |
dc.identifier.eissn | 1873-4995 | - |
dc.identifier.pmid | 33460670 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0168365921000274 | - |
dc.subject.keyword | Curcumin | - |
dc.subject.keyword | Heart-targeted extracellular vesicles | - |
dc.subject.keyword | Myocardial infarction | - |
dc.subject.keyword | miRNA-144-3p | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | 정보영 | - |
dc.citation.volume | 331 | - |
dc.citation.startPage | 62 | - |
dc.citation.endPage | 73 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CONTROLLED RELEASE, Vol.331 : 62-73, 2021-03 | - |
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