Cited 15 times in
Should Lymph Nodes Be Retrieved in Patients with Intrahepatic Cholangiocarcinoma? A Collaborative Korea-Japan Study
DC Field | Value | Language |
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dc.contributor.author | 강창무 | - |
dc.date.accessioned | 2021-04-29T16:49:23Z | - |
dc.date.available | 2021-04-29T16:49:23Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182037 | - |
dc.description.abstract | Background: This study was performed to investigate the oncologic role of lymph node (LN) management and to propose a surgical strategy for treating intrahepatic cholangiocarcinoma (IHCC). Methods: The medical records of patients with resected IHCC were retrospectively reviewed from multiple institutions in Korea and Japan. Short-term and long-term oncologic outcomes were analyzed according to lymph node metastasis (LNM). A nomogram to predict LNM in treating IHCC was established to propose a surgical strategy for managing IHCC. Results: A total of 1138 patients were enrolled. Of these, 413 patients underwent LN management and 725 did not. A total of 293 patients were found to have LNM. The No. 12 lymph node (36%) was the most frequent metastatic node, and the No. 8 lymph node (21%) was the second most common. LNM showed adverse long-term oncologic impact in patients with resected IHCC (14 months, 95% CI (11.4-16.6) vs. 74 months, 95% CI (57.2-90.8), p < 0.001), and the number of LNM (0, 1-3, 4≤) was also significantly related to negative oncologic impacts in patients with resected IHCC (74 months, 95% CI (57.2-90.8) vs. 19 months, 95% CI (14.4-23.6) vs. 11 months, 95% CI (8.1-13.8)), p < 0.001). Surgical retrieval of more than four (≥4) LNs could improve the survival outcome in resected IHCC with LNM (13 months, 95% CI (10.4-15.6)) vs. 30 months, 95% CI (13.1-46.9), p = 0.045). Based on preoperatively detectable parameters, a nomogram was established to predict LNM according to the tumor location. The AUC was 0.748 (95% CI: 0.706-0.788), and the Hosmer and Lemeshow goodness of fit test showed p = 0.4904. Conclusion: Case-specific surgical retrieval of more than four LNs is required in patients highly suspected to have LNM, based on a preoperative detectable parameter-based nomogram. Further prospective research is needed to validate the present surgical strategy in resected IHCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Should Lymph Nodes Be Retrieved in Patients with Intrahepatic Cholangiocarcinoma? A Collaborative Korea-Japan Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Chang Moo Kang | - |
dc.contributor.googleauthor | Kyung-Suk Suh | - |
dc.contributor.googleauthor | Nam-Joon Yi | - |
dc.contributor.googleauthor | Tae Ho Hong | - |
dc.contributor.googleauthor | Sang Jae Park | - |
dc.contributor.googleauthor | Keun Soo Ahn | - |
dc.contributor.googleauthor | Hiroki Hayashi | - |
dc.contributor.googleauthor | Sae Byeol Choi | - |
dc.contributor.googleauthor | Chi-Young Jeong | - |
dc.contributor.googleauthor | Takeshi Takahara | - |
dc.contributor.googleauthor | Shigehiro Shiozaki | - |
dc.contributor.googleauthor | Young Hoon Roh | - |
dc.contributor.googleauthor | Hee Chul Yu | - |
dc.contributor.googleauthor | Takumi Fukumoto | - |
dc.contributor.googleauthor | Ryusei Matsuyama | - |
dc.contributor.googleauthor | Uyama Naoki | - |
dc.contributor.googleauthor | Kazuki Hashida | - |
dc.contributor.googleauthor | Hyung Il Seo | - |
dc.contributor.googleauthor | Takehiro Okabayashi | - |
dc.contributor.googleauthor | Tomoo Kitajima | - |
dc.contributor.googleauthor | Sohei Satoi | - |
dc.contributor.googleauthor | Hiroaki Nagano | - |
dc.contributor.googleauthor | Hongbeom Kim | - |
dc.contributor.googleauthor | Kaoru Taira | - |
dc.contributor.googleauthor | Shoji Kubo | - |
dc.contributor.googleauthor | Dong Wook Choi | - |
dc.identifier.doi | 10.3390/cancers13030445 | - |
dc.contributor.localId | A00088 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 33503932 | - |
dc.subject.keyword | cholangiocarcinoma | - |
dc.subject.keyword | lymph nodes | - |
dc.subject.keyword | metastasis | - |
dc.subject.keyword | nomograms | - |
dc.contributor.alternativeName | Kang, Chang Moo | - |
dc.contributor.affiliatedAuthor | 강창무 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 445 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.13(3) : 445, 2021-01 | - |
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