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Soluble Urokinase-Type Plasminogen Activator Receptor, Changes of 24-Hour Blood Pressure, and Progression of Chronic Kidney Disease

DC Field Value Language
dc.contributor.author강신욱-
dc.contributor.author박성하-
dc.contributor.author박정탁-
dc.contributor.author유태현-
dc.contributor.author이찬주-
dc.contributor.author지종현-
dc.contributor.author한승혁-
dc.date.accessioned2021-04-29T16:44:09Z-
dc.date.available2021-04-29T16:44:09Z-
dc.date.issued2021-01-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181989-
dc.description.abstractBackground Soluble urokinase-type plasminogen activator receptor (suPAR) is associated with cardiovascular risks and poor renal outcomes. However, whether elevated suPAR levels are associated with 24-hour blood pressure patterns or kidney disease progression in patients with chronic kidney disease (CKD) is unclear. Methods and Results A total of 751 patients with CKD stage 1 to 5 were recruited from CMERC-HI (Cardiovascular and Metabolic Disease Etiology Research Center-High Risk) cohort study (2013-2018). The relationship of serum suPAR levels to 24-hour blood pressure parameters and CKD progression was analyzed. The median serum suPAR level was 1439.0 (interquartile range, 1026.2-2150.1) pg/mL, and the mean estimated glomerular filtration rate was 52.8±28.5 mL/min per 1.73 m2 at baseline. Patients with higher suPAR levels had significantly higher levels of office, 24-hour, daytime, and nighttime systolic blood pressure and nighttime diastolic blood pressure than those with lower suPAR levels. The highest suPAR tertile was associated with an increased risk of a reverse dipping pattern (odds ratio, 2.93; 95% CI, 1.27-6.76; P=0.01). During a follow-up of 43.2 (interquartile range, 27.0-55.6) months, the CKD progression occurred in 271 (36.1%) patients. The highest suPAR tertile was significantly associated with higher risk of CKD progression than the lowest tertile (hazard ratio [HR], 2.09; 95% CI, 1.37-3.21; P=0.001). When the relationship was reevaluated with respect to each dipping pattern (dipper, extreme dipper, nondipper, and reverse dipper), this association was consistent only in reverse dippers in whom the risk of CKD progression increased (HR, 1.43; 95% CI, 1.02-2.01; P=0.03) with every 1-unit increase in serum suPAR levels. Conclusions Elevated suPAR levels are independently associated with CKD progression, and this association is prominent in reverse dippers.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfJOURNAL OF THE AMERICAN HEART ASSOCIATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSoluble Urokinase-Type Plasminogen Activator Receptor, Changes of 24-Hour Blood Pressure, and Progression of Chronic Kidney Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJong Hyun Jhee-
dc.contributor.googleauthorBo Young Nam-
dc.contributor.googleauthorChan Joo Lee-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.identifier.doi10.1161/JAHA.120.017225-
dc.contributor.localIdA00053-
dc.contributor.localIdA01512-
dc.contributor.localIdA01654-
dc.contributor.localIdA02526-
dc.contributor.localIdA03238-
dc.contributor.localIdA03970-
dc.contributor.localIdA04304-
dc.relation.journalcodeJ01774-
dc.identifier.eissn2047-9980-
dc.identifier.pmid33325248-
dc.subject.keywordchronic kidney disease-
dc.subject.keyworddipping pattern-
dc.subject.keywordprogression of kidney disease-
dc.subject.keywordsoluble urokinase‐type plasminogen activator receptor-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.affiliatedAuthor강신욱-
dc.contributor.affiliatedAuthor박성하-
dc.contributor.affiliatedAuthor박정탁-
dc.contributor.affiliatedAuthor유태현-
dc.contributor.affiliatedAuthor이찬주-
dc.contributor.affiliatedAuthor지종현-
dc.contributor.affiliatedAuthor한승혁-
dc.citation.volume10-
dc.citation.number1-
dc.citation.startPagee017225-
dc.identifier.bibliographicCitationJOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol.10(1) : e017225, 2021-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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