Cited 79 times in
Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 정재호 | - |
dc.date.accessioned | 2021-04-29T16:40:48Z | - |
dc.date.available | 2021-04-29T16:40:48Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/181961 | - |
dc.description.abstract | In many cancers, tumour progression is associated with increased tissue stiffness. Yet, the mechanisms associating tissue stiffness with tumorigenesis and malignant transformation are unclear. Here we show that in gastric cancer cells, the stiffness of the extracellular matrix reversibly regulates the DNA methylation of the promoter region of the mechanosensitive Yes-associated protein (YAP). Reciprocal interactions between YAP and the DNA methylation inhibitors GRHL2, TET2 and KMT2A can cause hypomethylation of the YAP promoter and stiffness-induced oncogenic activation of YAP. Direct alteration of extracellular cues via in situ matrix softening reversed YAP activity and the epigenetic program. Our findings suggest that epigenetic reprogramming of the mechanophysical properties of the extracellular microenvironment of solid tumours may represent a therapeutic strategy for the inhibition of cancer progression. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Macmillan Publishers Limited | - |
dc.relation.isPartOf | NATURE BIOMEDICAL ENGINEERING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adaptor Proteins, Signal Transducing* / genetics | - |
dc.subject.MESH | Adaptor Proteins, Signal Transducing* / metabolism | - |
dc.subject.MESH | Carcinogenesis* / genetics | - |
dc.subject.MESH | Carcinogenesis* / metabolism | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | DNA Methylation* / genetics | - |
dc.subject.MESH | DNA Methylation* / physiology | - |
dc.subject.MESH | Epigenesis, Genetic / genetics | - |
dc.subject.MESH | Epigenesis, Genetic / physiology | - |
dc.subject.MESH | Extracellular Matrix* / chemistry | - |
dc.subject.MESH | Extracellular Matrix* / genetics | - |
dc.subject.MESH | Extracellular Matrix* / metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mechanotransduction, Cellular / genetics | - |
dc.subject.MESH | Mechanotransduction, Cellular / physiology | - |
dc.subject.MESH | Stomach Neoplasms* / genetics | - |
dc.subject.MESH | Stomach Neoplasms* / metabolism | - |
dc.subject.MESH | Stomach Neoplasms* / physiopathology | - |
dc.subject.MESH | Transcription Factors* / genetics | - |
dc.subject.MESH | Transcription Factors* / metabolism | - |
dc.subject.MESH | Tumor Microenvironment / genetics | - |
dc.subject.MESH | Tumor Microenvironment / physiology | - |
dc.title | Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Minjeong Jang | - |
dc.contributor.googleauthor | Jinhyeon An | - |
dc.contributor.googleauthor | Seung Won Oh | - |
dc.contributor.googleauthor | Joo Yeon Lim | - |
dc.contributor.googleauthor | Joon Kim | - |
dc.contributor.googleauthor | Jung Kyoon Choi | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.contributor.googleauthor | Pilnam Kim | - |
dc.identifier.doi | 10.1038/s41551-020-00657-x | - |
dc.contributor.localId | A03717 | - |
dc.relation.journalcode | J03462 | - |
dc.identifier.eissn | 2157-846X | - |
dc.identifier.pmid | 33288878 | - |
dc.identifier.url | https://www.nature.com/articles/s41551-020-00657-x | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | 정재호 | - |
dc.citation.volume | 5 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 114 | - |
dc.citation.endPage | 123 | - |
dc.identifier.bibliographicCitation | NATURE BIOMEDICAL ENGINEERING, Vol.5(1) : 114-123, 2021-01 | - |
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