21 31

Cited 0 times in

Antineutrophil Cytoplasmic Antibody Positivity Is Associated with Vascular Involvement in Behçet's Disease

DC FieldValueLanguage
dc.contributor.author이상원-
dc.contributor.author송정식-
dc.contributor.author박용범-
dc.contributor.author권혁찬-
dc.date.accessioned2021-04-01T02:38:18Z-
dc.date.available2021-04-01T02:38:18Z-
dc.date.issued2021-02-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181892-
dc.description.abstractPurpose: We investigated whether antineutrophil cytoplasmic antibody (ANCA) positivity is associated with vascular manifestations at diagnosis of Behçet's disease (BD) and poor outcomes during follow-up. Materials and methods: We retrospectively reviewed the medical records of 1060 patients with BD. Among them, 808 patients could be diagnosed with BD based on the revised version of the International Criteria for Behçet's Disease (ICBD) in 2014 (2014 ICBD criteria) and 588 patients could be diagnosed with BD based on the International Study Group (ISG) criteria proposed in 1990 (1990 ISG criteria). We examined the sites and patterns of vascular involvement in the BD patients at diagnosis and evaluated adverse outcomes during follow up, such as all-cause mortality, acute coronary syndrome, and deep vein thrombosis. Results: Among the 808 patients with BD based on the 2014 ICBD criteria, the rate of ANCA positivity at diagnosis was 2.2%. ANCA-positive BD patients exhibited a higher frequency of overall vascular manifestations (22.2% vs. 6.1%) and higher frequencies of vascular involvement in the upper extremities and visceral arteries than ANCA-negative BD patients (5.6% vs. 0.1% and 5.6% vs. 0.1%). Among the 588 BD patients based on the 1990 ISG criteria, similarly, ANCA-positive BD patients exhibited a higher frequency of vascular manifestations than ANCA-negative BD patients. ANCA positivity, however, did not seem to be associated with poor outcomes in BD patients during follow up. Conclusion: ANCA positivity in BD patients was found to be associated with cross-sectional vascular involvement in the upper extremities and visceral arteries at diagnosis but was not predictive of poor outcomes during follow-up.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAntineutrophil Cytoplasmic Antibody Positivity Is Associated with Vascular Involvement in Behçet's Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorMinyoung Kevin Kim-
dc.contributor.googleauthorHyeok Chan Kwon-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong Beom Park-
dc.contributor.googleauthorSang Won Lee-
dc.identifier.doi10.3349/ymj.2021.62.2.149-
dc.contributor.localIdA02824-
dc.contributor.localIdA02057-
dc.contributor.localIdA01579-
dc.contributor.localIdA06032-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid33527794-
dc.subject.keywordAdult-
dc.subject.keywordAntibodies, Antineutrophil Cytoplasmic / immunology*-
dc.subject.keywordBehcet Syndrome / diagnosis-
dc.subject.keywordBehcet Syndrome / immunology*-
dc.subject.keywordBlood Vessels / pathology*-
dc.subject.keywordCross-Sectional Studies-
dc.subject.keywordFemale-
dc.subject.keywordFollow-Up Studies-
dc.subject.keywordHumans-
dc.subject.keywordMale-
dc.subject.keywordOutcome Assessment, Health Care-
dc.subject.keywordRetrospective Studies-
dc.contributor.alternativeNameLee, Sang Won-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor권혁찬-
dc.citation.volume62-
dc.citation.number2-
dc.citation.startPage149-
dc.citation.endPage158-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.62(2) : 149-158, 2021-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.