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Risk Factors for Predicting Hypoxia in Adult Patients Undergoing Bronchoscopy under Sedation

Authors
 Choi, Ji Soo  ;  Lee, Eun Hye  ;  Lee, Sang Hoon  ;  Leem, Ah Young  ;  Chung, Kyung Soo  ;  Kim, Song Yee  ;  Jung, Ji Ye  ;  Kang, Young Ae  ;  Park, Moo Suk  ;  Chang, Joon  ;  Kim, Young Sam 
Citation
 TUBERCULOSIS AND RESPIRATORY DISEASES, Vol.83(4) : 276-282, 2020-10 
Journal Title
TUBERCULOSIS AND RESPIRATORY DISEASES
ISSN
 1738-3536 
Issue Date
2020-10
Keywords
Bronchoscopy ; Hypoxia ; Risk Factors
Abstract
Background: Flexible bronchoscopy is one of the essential procedures for the diagnosis and treatment of pulmonary diseases. The purpose of this study was to identify the risk factors associated with the occurrence of hypoxia in adults undergoing flexible bronchoscopy under sedation. Methods: We retrospectively analyzed 2,520 patients who underwent flexible bronchoscopy under sedation at our tertiary care university hospital in South Korea January 1, 2013-December 31, 2014. Hypoxia was defined as more than 5%-point reduction in the baseline percutaneous oxygen saturation (SpO(2)) or SpO(2) <90% for >1 minute during the procedure. Results: The mean age was 64.7 +/- 13.5, and 565 patients developed hypoxia during the procedure. The mean sedation duration and midazolam dose for sedation were 31.1 minutes and 3.9 mg, respectively. The bivariate analysis showed that older age, a low forced expiratory volume in one second (FEV1), use of endobronchial ultrasound, the duration of sedation, and the midazolam dose were associated with the occurrence of hypoxia during the procedure, while the multivariate analysis found that age >60 (odds ratio [OR], 1.32), a low FEV1 (OR, 0.99), and a longer duration of sedation (>40 minutes; OR, 1.33) were significant risk factors. Conclusion: The findings suggest that patients older than age 60 and those with a low FEV1 tend to develop hypoxia during the bronchoscopy under sedation. Also, longer duration of sedation (>40 minutes) was a significant risk factor for hypoxia.
Files in This Item:
T202006451.pdf Download
DOI
10.4046/trd.2020.0002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Song Yee(김송이) ORCID logo https://orcid.org/0000-0001-8627-486X
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Lee, Sang Hoon(이상훈) ORCID logo https://orcid.org/0000-0002-7706-5318
Lee, Eun Hye(이은혜) ORCID logo https://orcid.org/0000-0003-2570-3442
Leem, Ah Young(임아영) ORCID logo https://orcid.org/0000-0001-5165-3704
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Jung, Kyung Soo(정경수) ORCID logo https://orcid.org/0000-0003-1604-8730
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
Choi, Ji Soo(최지수) ORCID logo https://orcid.org/0000-0003-2716-6775
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181806
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