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First-in-human evaluation of [C-11]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain

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dc.contributor.authorKim, Min-Jeong-
dc.contributor.authorLee, Jae-Hoon-
dc.contributor.authorAnaya, Fernanda Juarez-
dc.contributor.authorHong, Jinsoo-
dc.contributor.authorMiller, William-
dc.contributor.authorTelu, Sanjay-
dc.contributor.authorSingh, Prachi-
dc.contributor.authorCortes, Michelle Y.-
dc.contributor.authorHenry, Katharine-
dc.contributor.authorTye, George L.-
dc.contributor.authorFrankland, Michael P.-
dc.contributor.authorSantamaria, Jose A. Montero-
dc.contributor.authorLiow, Jeih-San-
dc.contributor.authorZoghbi, Sami S.-
dc.contributor.authorFujita, Masahiro-
dc.contributor.authorPike, Victor W.-
dc.contributor.authorInnis, Robert B.-
dc.date.accessioned2021-03-17T09:08:04Z-
dc.date.available2021-03-17T09:08:04Z-
dc.date.created2021-03-15-
dc.date.issued2020-12-
dc.identifier.issn1619-7070-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181794-
dc.description.abstractPurpose This study assessed whether the newly developed PET radioligand [C-11]PS13, which has shown excellent in vivo selectivity in previous animal studies, could be used to quantify constitutive levels of cyclooxygenase-1 (COX-1) in healthy human brain. Methods Brain test-retest scans with concurrent arterial blood samples were obtained in 10 healthy individuals. The one- and unconstrained two-tissue compartment models, as well as the Logan graphical analysis were compared, and test-retest reliability and time-stability of total distribution volume (V-T) were assessed. Correlation analyses were conducted between brain regional V-T and COX-1 transcript levels provided in the Allen Human Brain Atlas. Results In the brain, [C-11]PS13 showed highest uptake in the hippocampus and occipital cortex. The pericentral cortex also showed relatively higher uptake compared with adjacent neocortices. The two-tissue compartment model showed the best fit in all the brain regions, and the results from the Logan graphical analysis were consistent with those from the two-tissue compartment model. V-T values showed excellent test-retest variability (range 6.0-8.5%) and good reliability (intraclass correlation coefficient range 0.74-0.87). V-T values also showed excellent time-stability in all brain regions, confirming that there was no radiometabolite accumulation and that shorter scans were still able to reliably measure V-T. Significant correlation was observed between V-T and COX-1 transcript levels (r = 0.82, P = 0.007), indicating that [C-11]PS13 binding reflects actual COX-1 density in the human brain. Conclusions These results from the first-in-human evaluation of the ability of [C-11]PS13 to image COX-1 in the brain justifies extending the study to disease populations with neuroinflammation.-
dc.language영어-
dc.publisherSPRINGER-
dc.relation.isPartOfEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING-
dc.titleFirst-in-human evaluation of [C-11]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain-
dc.typeArticle-
dc.contributor.googleauthorKim, Min-Jeong-
dc.contributor.googleauthorLee, Jae-Hoon-
dc.contributor.googleauthorAnaya, Fernanda Juarez-
dc.contributor.googleauthorHong, Jinsoo-
dc.contributor.googleauthorMiller, William-
dc.contributor.googleauthorTelu, Sanjay-
dc.contributor.googleauthorSingh, Prachi-
dc.contributor.googleauthorCortes, Michelle Y.-
dc.contributor.googleauthorHenry, Katharine-
dc.contributor.googleauthorTye, George L.-
dc.contributor.googleauthorFrankland, Michael P.-
dc.contributor.googleauthorSantamaria, Jose A. Montero-
dc.contributor.googleauthorLiow, Jeih-San-
dc.contributor.googleauthorZoghbi, Sami S.-
dc.contributor.googleauthorFujita, Masahiro-
dc.contributor.googleauthorPike, Victor W.-
dc.contributor.googleauthorInnis, Robert B.-
dc.identifier.doi10.1007/s00259-020-04855-2-
dc.relation.journalcodeJ00833-
dc.identifier.eissn1619-7089-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s00259-020-04855-2-
dc.subject.keywordCyclooxygenase-1-
dc.subject.keywordPositron emission tomography-
dc.subject.keywordInflammation-
dc.subject.keywordTest-retest reliability-
dc.subject.keywordNeuroimaging-
dc.contributor.affiliatedAuthorLee, Jae-Hoon-
dc.identifier.scopusid2-s2.0-85084580685-
dc.identifier.wosid000532139600002-
dc.citation.titleEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING-
dc.citation.titleEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING-
dc.citation.volume47-
dc.citation.number13-
dc.citation.startPage3143-
dc.citation.endPage3151-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.47(13) : 3143-3151, 2020-12-
dc.identifier.rimsid67802-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.journalClass1-
dc.subject.keywordAuthorCyclooxygenase-1-
dc.subject.keywordAuthorPositron emission tomography-
dc.subject.keywordAuthorInflammation-
dc.subject.keywordAuthorTest-retest reliability-
dc.subject.keywordAuthorNeuroimaging-
dc.subject.keywordPlusMICROGLIA-
dc.subject.keywordPlusREPRODUCIBILITY-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusATLAS-
dc.subject.keywordPlusBLOOD-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryRadiology, Nuclear Medicine & Medical Imaging-
dc.relation.journalResearchAreaRadiology, Nuclear Medicine & Medical Imaging-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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