25 42

Cited 0 times in

Metformin and Gastrointestinal Cancer Development in Newly Diagnosed Type 2 Diabetes: A Population-Based Study in Korea

DC FieldValueLanguage
dc.contributor.author이병완-
dc.contributor.author이용호-
dc.date.accessioned2021-01-19T08:15:19Z-
dc.date.available2021-01-19T08:15:19Z-
dc.date.issued2020-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181533-
dc.description.abstractIntroduction: Clinical studies have produced conflicting results on the effects of metformin on gastrointestinal cancer development. We aimed to investigate the association between metformin use and stomach, colon, liver, and pancreatic cancer development among patients with newly diagnosed, drug-naïve type 2 diabetes. Methods: This retrospective study evaluated propensity score-matched patients with newly diagnosed type 2 diabetes from the Korean National Health Insurance Service database. Metformin users were categorized into tertiles according to the cumulative dose or duration of metformin treatment, and the risks of gastrointestinal cancers were compared. Results: Metformin users had reduced risks of developing stomach cancer (hazard ratio [HR]: 0.841, 95% confidence interval [CI]: 0.797-0.887), colon cancer (HR: 0.865, 95% CI: 0.822-0.91), and liver cancer (HR: 0.709, 95% CI: 0.675-0.746; P < 0.001). However, metformin users did not have a reduced overall risk of pancreatic cancer (HR: 1.335, 95% CI: 1.209-1.475; P < 0.001). The risks tended to decrease at higher cumulative doses and durations of metformin use, with significantly reduced risks of all 4 cancers at the highest cumulative dose (≥1,200,000 mg) and the longest duration (≥2,000 days) of metformin use. Discussion: This population-based data suggest that metformin could be associated with reductions in the risks of stomach, colon, and liver cancers, as well a reduced risk of pancreatic cancer in some subgroups. Metformin has benefit as a first-line treatment for type 2 diabetes mellitus. A further role in cancer risk reduction could be studied in controlled trials.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWolters Kluwer Health-
dc.relation.isPartOfCLINICAL AND TRANSLATIONAL GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMetformin and Gastrointestinal Cancer Development in Newly Diagnosed Type 2 Diabetes: A Population-Based Study in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJi Hong You-
dc.contributor.googleauthorSun Ok Song-
dc.contributor.googleauthorMin Jin Kang-
dc.contributor.googleauthorYoon Young Cho-
dc.contributor.googleauthorSun Wook Kim-
dc.contributor.googleauthorSung Hwan Suh-
dc.contributor.googleauthorSujin Lee-
dc.contributor.googleauthorYong-Ho Lee-
dc.contributor.googleauthorByung-Wan Lee-
dc.identifier.doi10.14309/ctg.0000000000000254-
dc.contributor.localIdA02796-
dc.contributor.localIdA02989-
dc.contributor.localIdA02989-
dc.relation.journalcodeJ03632-
dc.identifier.eissn2155-384X-
dc.identifier.pmid33105165-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.affiliatedAuthor이병완-
dc.contributor.affiliatedAuthor이용호-
dc.contributor.affiliatedAuthor이용호-
dc.citation.volume11-
dc.citation.number11-
dc.citation.startPagee00254-
dc.identifier.bibliographicCitationCLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, Vol.11(11) : e00254, 2020-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.