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Evaluation of factors related to Anaesthesia-induced Lens opacity in experimental mice

DC FieldValueLanguage
dc.contributor.author서경률-
dc.date.accessioned2021-01-19T08:14:23Z-
dc.date.available2021-01-19T08:14:23Z-
dc.date.issued2020-01-
dc.identifier.issn1738-6055-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181523-
dc.description.abstractTo investigate conditions that cause temporal lens opacity, we tested chemical and physical factors, such as anaesthesia dose, ocular surface dryness, and infrared (IR) light exposure in anaesthetised C57BL/6 N mice. Mice were anaesthetised with a low (80%; tiletamine/zolazepam 32 mg/kg and xylazine 8 mg/kg, intraperitoneal injection) or high (120%; 48 mg/kg and 12 mg/kg) dose of anaesthetic and examined every 5 min from 10 to 30 min after anaesthesia was induced. Lens opacity levels were assessed and graded (1-6) using the standard classification system. Regardless of the anaesthetic dose, lens opacity grade was 1-2 in moisturised eyes with application of 0.5% carboxymethylcellulose, and 5-6 in dry ocular surface conditions. Lens opacity in mice with high-dose anaesthetic in the dry ocular surface condition was not different from that of mice with low-dose anaesthetic. Lens opacity grade 1-2 was noted in eyes in the wet ocular surface condition, regardless of IR light exposure. During IR light exposure in eyes in the dry ocular surface condition, lens opacity (grade 6) in mice with high-dose anaesthetic was not different from that (grade 6) in mice with low-dose anaesthetic. We demonstrated that ocular surface dryness might be a relevant factor for the formation and progression of lens opacity in anesthetized C57BL/6 N mice. Anaesthesia dose and IR light exposure did not strongly influence lens opacity formation. Furthermore, eyes with corneal dryness-induced lens opacity recovered to normal status without additional intervention.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher한국실험동물학회-
dc.relation.isPartOfLaboratory Animal Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEvaluation of factors related to Anaesthesia-induced Lens opacity in experimental mice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorHun Lee-
dc.contributor.googleauthorHong Kyung Kim-
dc.contributor.googleauthorHae Sol Shin-
dc.contributor.googleauthorSoo Jung Han-
dc.contributor.googleauthorSangchul Yoon-
dc.contributor.googleauthorJe Kyung Seong-
dc.contributor.googleauthorKyoung Yul Seo-
dc.identifier.doi10.1186/s42826-019-0031-z-
dc.contributor.localIdA01870-
dc.relation.journalcodeJ02149-
dc.identifier.eissn2233-7660-
dc.identifier.pmid32206608-
dc.subject.keywordAnaesthetic dose-
dc.subject.keywordC57BL/6 N mice-
dc.subject.keywordInfrared light-
dc.subject.keywordLens opacity-
dc.subject.keywordOcular surface dryness-
dc.contributor.alternativeNameSeo, Kyoung Yul-
dc.contributor.affiliatedAuthor서경률-
dc.citation.volume36-
dc.citation.number1-
dc.citation.startPage1-
dc.citation.endPage28-
dc.identifier.bibliographicCitationLaboratory Animal Research, Vol.36(1) : 1-28, 2020-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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