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Prevalence and prognosis of the 2018 vs 2008 AHA definitions of apparent treatment-resistant hypertension in high-risk hypertension patients

DC FieldValueLanguage
dc.contributor.author강석민-
dc.contributor.author박성하-
dc.contributor.author오재원-
dc.contributor.author이상학-
dc.contributor.author이찬주-
dc.contributor.author전경현-
dc.date.accessioned2021-01-19T08:13:41Z-
dc.date.available2021-01-19T08:13:41Z-
dc.date.issued2020-11-
dc.identifier.issn1524-6175-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181518-
dc.description.abstractResistant hypertension was defined according to the 2008 scientific statement as office blood pressure ≥ 140/90 mm Hg and the 2018 scientific statement as office blood pressure ≥ 130/80 mm Hg. We investigated the prognostic significance of lowered blood pressure threshold for defining resistant hypertension in the 2018 American Heart Association scientific statement compared with that in the 2008 scientific statement. The participants of this prospective cohort were enrolled from December 2013 to November 2018. Major adverse cardiovascular events (MACEs) were defined as a composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and heart failure hospitalization. Renal event was defined as a ≥ 50% decline in estimated glomerular filtration rate or progression to end-stage renal disease. A total of 206 patients among 2018 (10.2%) were diagnosed with resistant hypertension by the previous definition (≥140/90 mm Hg), and 276 patients among 2011 (13.7%) were diagnosed with resistant hypertension by the updated definition (≥130/80 mm Hg). During a median follow-up of 4.5 years, 33 MACEs (3.7 per 1000 patient-years) and 164 renal events (19.9 per 1000 patient-years) occurred in the study population. Treatment-resistant hypertension groups had a higher incidence rate of MACEs and renal events than the control groups. In multivariate Cox proportional hazards regression analysis, resistant hypertension by both definitions was significantly associated with increased risk of MACE and renal event. Both the previous and updated definitions of resistant hypertension were significant predictors of MACEs and renal events. This finding supports the adoption of the updated criteria for resistant hypertension in clinical practice.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWiley Periodicals Inc.-
dc.relation.isPartOfJOURNAL OF CLINICAL HYPERTENSION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePrevalence and prognosis of the 2018 vs 2008 AHA definitions of apparent treatment-resistant hypertension in high-risk hypertension patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorKyeong-Hyeon Chun-
dc.contributor.googleauthorChan Joo Lee-
dc.contributor.googleauthorJaewon Oh-
dc.contributor.googleauthorSang-Hak Lee-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorKazuomi Kario-
dc.contributor.googleauthorSungha Park-
dc.identifier.doi10.1111/jch.14043-
dc.contributor.localIdA00037-
dc.contributor.localIdA01512-
dc.contributor.localIdA01512-
dc.contributor.localIdA02395-
dc.contributor.localIdA02395-
dc.contributor.localIdA02833-
dc.contributor.localIdA02833-
dc.contributor.localIdA03238-
dc.contributor.localIdA03238-
dc.contributor.localIdA03500-
dc.contributor.localIdA03500-
dc.relation.journalcodeJ01320-
dc.identifier.eissn1751-7176-
dc.identifier.pmid32951267-
dc.subject.keywordmajor adverse cardiovascular event-
dc.subject.keywordoffice blood pressure-
dc.subject.keywordrenal outcome-
dc.subject.keywordresistant hypertension-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.contributor.affiliatedAuthor박성하-
dc.contributor.affiliatedAuthor박성하-
dc.contributor.affiliatedAuthor오재원-
dc.contributor.affiliatedAuthor오재원-
dc.contributor.affiliatedAuthor이상학-
dc.contributor.affiliatedAuthor이상학-
dc.contributor.affiliatedAuthor이찬주-
dc.contributor.affiliatedAuthor이찬주-
dc.contributor.affiliatedAuthor전경현-
dc.contributor.affiliatedAuthor전경현-
dc.citation.volume22-
dc.citation.number11-
dc.citation.startPage2093-
dc.citation.endPage2102-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL HYPERTENSION, Vol.22(11) : 2093-2102, 2020-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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