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Less dementia after catheter ablation for atrial fibrillation: a nationwide cohort study

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dc.contributor.author김대훈-
dc.contributor.author김종윤-
dc.contributor.author김태훈-
dc.contributor.author박희남-
dc.contributor.author엄재선-
dc.contributor.author유희태-
dc.contributor.author이문형-
dc.contributor.author장은선-
dc.contributor.author정보영-
dc.date.accessioned2021-01-19T08:12:11Z-
dc.date.available2021-01-19T08:12:11Z-
dc.date.issued2020-12-
dc.identifier.issn0195-668X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181509-
dc.description.abstractAims: Accumulating evidence shows that atrial fibrillation (AF) is associated with an increased risk of dementia. Catheter ablation for AF prolongs the duration of sinus rhythm, thereby improving the quality of life. We investigated the association of catheter ablation for AF with the occurrence of dementia. Methods and results: Using the Korean National Health Insurance Service database, among 194 928 adults with AF treated with ablation or medical therapy (antiarrhythmic or rate control drugs) between 1 January 2005 and 31 December 2015, we studied 9119 patients undergoing ablation and 17 978 patients managed with medical therapy. The time-at-risk was counted from the first medical therapy, and ablation was analysed as a time-varying exposure. Propensity score-matching was used to correct for differences between the groups. During a median follow-up of 52 months, compared with patients with medical therapy, ablated patients showed lower incidence and risk of overall dementia (8.1 and 5.6 per 1000 person-years, respectively; hazard ratio 0.73, 95% confidence interval 0.58-0.93). The associations between ablation and dementia risk were consistently observed after additionally censoring for incident stroke (hazard ratio 0.76, 95% confidence interval 0.61-0.95) and more pronounced in cases of ablation success whereas no significant differences observed in cases of ablation failure. Ablation was associated with lower risks of dementia subtypes including Alzheimer's disease and vascular dementia. Conclusion: In this nationwide cohort of AF patients treated with catheter ablation or medical therapy, ablation was associated with decreased dementia risk. This relationship was evident after censoring for stroke and adjusting for clinical confounders.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfEUROPEAN HEART JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleLess dementia after catheter ablation for atrial fibrillation: a nationwide cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorDaehoon Kim-
dc.contributor.googleauthorPil-Sung Yang-
dc.contributor.googleauthorJung-Hoon Sung-
dc.contributor.googleauthorEunsun Jang-
dc.contributor.googleauthorHee Tae Yu-
dc.contributor.googleauthorTae-Hoon Kim-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorJong-Youn Kim-
dc.contributor.googleauthorHui-Nam Pak-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorGregory Y H Lip-
dc.contributor.googleauthorBoyoung Joung-
dc.identifier.doi10.1093/eurheartj/ehaa726-
dc.contributor.localIdA00373-
dc.contributor.localIdA00926-
dc.contributor.localIdA00926-
dc.contributor.localIdA01085-
dc.contributor.localIdA01085-
dc.contributor.localIdA01776-
dc.contributor.localIdA01776-
dc.contributor.localIdA02337-
dc.contributor.localIdA02337-
dc.contributor.localIdA02535-
dc.contributor.localIdA02535-
dc.contributor.localIdA02766-
dc.contributor.localIdA02766-
dc.contributor.localIdA05608-
dc.contributor.localIdA05608-
dc.contributor.localIdA03609-
dc.contributor.localIdA03609-
dc.relation.journalcodeJ00805-
dc.identifier.eissn1522-9645-
dc.identifier.pmid33022705-
dc.identifier.urlhttps://academic.oup.com/eurheartj/article/41/47/4483/5918337-
dc.subject.keywordAtrial fibrillation-
dc.subject.keywordCatheter ablation-
dc.subject.keywordDementia-
dc.contributor.alternativeNameKim, Dae Hoon-
dc.contributor.affiliatedAuthor김대훈-
dc.contributor.affiliatedAuthor김종윤-
dc.contributor.affiliatedAuthor김종윤-
dc.contributor.affiliatedAuthor김태훈-
dc.contributor.affiliatedAuthor김태훈-
dc.contributor.affiliatedAuthor박희남-
dc.contributor.affiliatedAuthor박희남-
dc.contributor.affiliatedAuthor엄재선-
dc.contributor.affiliatedAuthor엄재선-
dc.contributor.affiliatedAuthor유희태-
dc.contributor.affiliatedAuthor유희태-
dc.contributor.affiliatedAuthor이문형-
dc.contributor.affiliatedAuthor이문형-
dc.contributor.affiliatedAuthor장은선-
dc.contributor.affiliatedAuthor장은선-
dc.contributor.affiliatedAuthor정보영-
dc.contributor.affiliatedAuthor정보영-
dc.citation.volume41-
dc.citation.number47-
dc.citation.startPage4483-
dc.citation.endPage4493-
dc.identifier.bibliographicCitationEUROPEAN HEART JOURNAL, Vol.41(47) : 4483-4493, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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