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Reirradiation with intensity-modulated radiation therapy for recurrent or secondary head and neck cancer: Meta-analysis and systematic review

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dc.contributor.author금웅섭-
dc.date.accessioned2021-01-19T08:09:57Z-
dc.date.available2021-01-19T08:09:57Z-
dc.date.issued2020-09-
dc.identifier.issn1043-3074-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181489-
dc.description.abstractBackground: To summarize outcomes of reirradiation with intensity-modulated radiotherapy (IMRT) for recurrent or secondary head and neck cancer (HNC). Methods: Primary endpoints were 2-year local control (LC) and overall survival (OS). Studies involving only recurrent nasopharyngeal patients with cancer were excluded. Results: A total of 17 studies involving 1635 patients were included. Fourteen (82%) of those were retrospective, and 15 (88%) were from single institution. Reirradiation with IMRT produced pooled 2-year LC and OS rates of 52% (95% confidence interval [CI], 46%-57%) and 46% (95% CI, 41%-50%), respectively. In subgroup analyses, the rate of salvage surgery (<42% vs ≥42%) influenced the pooled 2-year LC rate (45.9% vs 58.5%, P = .011). The pooled rates of late grade ≥ 3 and grade 5 toxicities were 26% (95% CI, 20%-32%) and 3.1% (95% CI, 2%-5%), respectively. Conclusions: Reirradiation with IMRT was an effective modality compared to historical outcomes in the pre-IMRT era.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherJohn Wiley And Sons-
dc.relation.isPartOfHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleReirradiation with intensity-modulated radiation therapy for recurrent or secondary head and neck cancer: Meta-analysis and systematic review-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorJeongshim Lee-
dc.contributor.googleauthorIn-Soo Shin-
dc.contributor.googleauthorWoo Chul Kim-
dc.contributor.googleauthorWon Sup Yoon-
dc.contributor.googleauthorWoong Sub Koom-
dc.contributor.googleauthorChai Hong Rim-
dc.identifier.doi10.1002/hed.26264-
dc.contributor.localIdA00273-
dc.relation.journalcodeJ00963-
dc.identifier.eissn1097-0347-
dc.identifier.pmid32437021-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/hed.26264-
dc.subject.keywordhead and neck cancer-
dc.subject.keywordintensity-modulated radiotherapy-
dc.subject.keywordmeta-analysis-
dc.subject.keywordrecurrence-
dc.subject.keywordreirradiation-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.affiliatedAuthor금웅섭-
dc.citation.volume42-
dc.citation.number9-
dc.citation.startPage2473-
dc.citation.endPage2485-
dc.identifier.bibliographicCitationHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.42(9) : 2473-2485, 2020-09-
dc.identifier.rimsid67348-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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