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Motor Cerebellar Connectivity and Future Development of Freezing of Gait in De Novo Parkinson's Disease

DC FieldValueLanguage
dc.contributor.author백경원-
dc.contributor.author손영호-
dc.contributor.author예병석-
dc.contributor.author유한수-
dc.contributor.author이양현-
dc.contributor.author이필휴-
dc.contributor.author정석종-
dc.date.accessioned2021-01-19T08:07:34Z-
dc.date.available2021-01-19T08:07:34Z-
dc.date.issued2020-12-
dc.identifier.issn0885-3185-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181472-
dc.description.abstractObjective: To investigate the role of motor cerebellar connectivity in future development of freezing of gait, because it is a complex network disorder in Parkinson's disease (PD). Methods: We recruited 26 de novo patients with PD who experienced freezing of gait within 5 years from magnetic resonance imaging acquisition (vulnerable PD group), 61 patients with PD who had not experienced freezing of gait within 5 years (resistant PD group), and 27 healthy control subjects. We compared the resting state functional connectivity between the motor cerebellum and the whole brain between the groups. In addition, we evaluated the relationship between motor cerebellar connectivity and freezing of gait latency. Results: The vulnerable PD group had increased functional connectivity between the motor cerebellum and parieto-occipito-temporal association cortices compared with the control group or the resistant PD group. Connectivity between lobule VI and the right superior parietal lobule, right fusiform gyrus, and left inferior temporal gyrus; between lobule VIIb and the right superior parietal lobule, right hippocampus, and right middle temporal gyrus; and between lobule VIIIb and the bilateral fusiform gyri, right middle occipital gyrus, and bilateral parietal lobes was inversely proportional to freezing of gait latency. The freezing of gait latency-related cortical functional connectivity from the motor cerebellum was also significantly higher in the vulnerable PD group compared with the control group, as well as the resistant PD group. Conclusions: The data suggest that the motor cerebellar functional connectivity with the posterior cortical areas play an important role in future development of freezing of gait in PD. © 2020 International Parkinson and Movement Disorder Society.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfMOVEMENT DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMotor Cerebellar Connectivity and Future Development of Freezing of Gait in De Novo Parkinson's Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorJin Ho Jung-
dc.contributor.googleauthorBo-Hyun Kim-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorHan Soo Yoo-
dc.contributor.googleauthorYang Hyun Lee-
dc.contributor.googleauthorKyoungwon Baik-
dc.contributor.googleauthorByoung Seok Ye-
dc.contributor.googleauthorYoung H Sohn-
dc.contributor.googleauthorJong-Min Lee-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1002/mds.28243-
dc.contributor.localIdA05133-
dc.contributor.localIdA01982-
dc.contributor.localIdA01982-
dc.contributor.localIdA04603-
dc.contributor.localIdA04603-
dc.contributor.localIdA05367-
dc.contributor.localIdA05367-
dc.contributor.localIdA05714-
dc.contributor.localIdA05714-
dc.contributor.localIdA03270-
dc.contributor.localIdA03270-
dc.contributor.localIdA04666-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ02275-
dc.identifier.eissn1531-8257-
dc.identifier.pmid32926481-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/mds.28243-
dc.subject.keywordParkinson's disease-
dc.subject.keywordcerebellar connectivity-
dc.subject.keywordfreezing of gait-
dc.contributor.alternativeNameBaik, Kyoungwon-
dc.contributor.affiliatedAuthor백경원-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor정석종-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume35-
dc.citation.number12-
dc.citation.startPage2240-
dc.citation.endPage2249-
dc.identifier.bibliographicCitationMOVEMENT DISORDERS, Vol.35(12) : 2240-2249, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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