0 491

Cited 9 times in

Clinical and Striatal Dopamine Transporter Predictors of Mild Behavioral Impairment in Drug-Naive Parkinson Disease

DC Field Value Language
dc.contributor.author손영호-
dc.contributor.author예병석-
dc.contributor.author유한수-
dc.contributor.author윤미진-
dc.contributor.author이필휴-
dc.contributor.author정석종-
dc.date.accessioned2021-01-19T08:07:19Z-
dc.date.available2021-01-19T08:07:19Z-
dc.date.issued2020-11-
dc.identifier.issn0363-9762-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181471-
dc.description.abstractPurpose: Neuropsychiatric symptoms are important and frequent nonmotor features in Parkinson disease (PD). We explored mild behavioral impairment (MBI) in drug-naive patients with PD and its clinical and dopamine transporter (DAT) correlates. Methods: We recruited 275 drug-naive patients with PD who had undergone Unified Parkinson's Disease Rating Scale, a neuropsychological battery, Neuropsychiatric Inventory, and N-(3-[F]fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) PET within 6 months. Patients with PD were divided into groups without MBI (PD-MBI-, n = 186) and with MBI (PD-MBI+, n = 89) according to the Neuropsychiatric Inventory. We performed comparative analysis of DAT availability, cognitive function, and motor deficits between the groups. Results: Mild behavioral impairment was found in 32.4% of PD patients at the time of diagnosis, and affective dysregulation and decreased motivation were the 2 most common neuropsychiatric domains. Dopamine transporter availability in the anterior caudate (odds ratio, 0.60; P = 0.016) and anterior putamen (odds ratio, 0.58; P = 0.008) was associated with the development of MBI in PD. PD-MBI+ group had a lower z-score in memory-related tests and Stroop color reading test than PD-MBI- group. PD-MBI+ group had a higher Unified Parkinson's Disease Rating Scale motor score after controlling for DAT availability in the posterior putamen than PD-MBI- group (P = 0.007). Conclusions: This study suggests that early behavioral impairment is associated with more pathological involvement in the anterior striatum, memory and frontal dysfunction, and motor deficits, which could be regarded as a different phenotype in PD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott-
dc.relation.isPartOfCLINICAL NUCLEAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHBehavior*-
dc.subject.MESHDopamine Plasma Membrane Transport Proteins / metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeostriatum / metabolism*-
dc.subject.MESHParkinson Disease / metabolism*-
dc.subject.MESHParkinson Disease / physiopathology-
dc.titleClinical and Striatal Dopamine Transporter Predictors of Mild Behavioral Impairment in Drug-Naive Parkinson Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorHan Soo Yoo-
dc.contributor.googleauthorSangwon Lee-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorByoung Seok Ye-
dc.contributor.googleauthorYoung H Sohn-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1097/RLU.0000000000003281-
dc.contributor.localIdA01982-
dc.contributor.localIdA04603-
dc.contributor.localIdA05367-
dc.contributor.localIdA02550-
dc.contributor.localIdA03270-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ00595-
dc.identifier.eissn1536-0229-
dc.identifier.pmid32956117-
dc.identifier.urlhttps://journals.lww.com/nuclearmed/Fulltext/2020/11000/Clinical_and_Striatal_Dopamine_Transporter.35.aspx-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume45-
dc.citation.number11-
dc.citation.startPagee463-
dc.citation.endPagee468-
dc.identifier.bibliographicCitationCLINICAL NUCLEAR MEDICINE, Vol.45(11) : e463-e468, 2020-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.