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Korean male active smokers: quantifying their smoking habits and the transformation factor among biomarkers in urine and blood

 Jiyeon Yang  ;  Shervin Hashemi  ;  Wonseok Han  ;  Chaelin Lee  ;  Younseok Kang  ;  Youngwook Lim 
 BIOMARKERS, Vol.25(8) : 659-669, 2020-11 
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Biological matrices ; NMR ; biomarker analysis ; smoking topography ; tobacco science ; transformation factor
Objectives: The aim of the study was to investigate the correlations within the levels of biomarkers in different biological matrices, along with smoking topography variables, among active male smokers in Korea. Accordingly, we defined a transformation factor to convert level of tobacco smoke exposure and impact biomarkers from different biometrics. Methods: We examined smoking topography of recruited volunteers using a self-reporting survey. The level of tobacco smoke exposure and impact biomarkers in subjects' urine and blood were analysed. Results were used to assess the correlations between the topography survey items with biomarkers in biological matrices. The relationship between the biomarkers in urine and blood was analysed. Accordingly, we defined a transformation factor as the ratio of different biomarkers in urine and blood matrices. Results: Significant correlations among smoking topography variables and biomarkers were found. Besides, a strong significant association was found among urine and blood cotinine (ρ = 0.817) and NMR (ρ = 0.905). Urine vs blood cotinine and NMR transformation factors were calculated to be 6.17 L-Blood/g-Creatinine and 10.2, respectively. Conclusions: The validated transformation factor connects epidemiological cohort studies with tobacco smoking exposure risk assessment. Hence, this study might be beneficial for further habit-based smoking risk assessments to obtain successful regional cession policies.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Yang, Ji Yeon(양지연)
Lim, Young Wook(임영욱) ORCID logo https://orcid.org/0000-0001-8845-2850
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