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Effect of sex hormones on coronavirus disease 2019: an analysis of 5,061 laboratory-confirmed cases in South Korea

DC FieldValueLanguage
dc.contributor.author김용찬-
dc.contributor.author박윤수-
dc.contributor.author송영구-
dc.contributor.author이재훈-
dc.contributor.author조시현-
dc.date.accessioned2021-01-19T08:04:37Z-
dc.date.available2021-01-19T08:04:37Z-
dc.date.issued2020-12-
dc.identifier.issn1072-3714-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181455-
dc.description.abstractObjective: To evaluate the effect of female sex hormones on the clinical outcomes of coronavirus disease 2019 patients using national claims data. Methods: This retrospective cohort study used the Health Insurance Review and Assessment data of 5,061 adult patients with laboratory-confirmed coronavirus disease 2019 in South Korea from January 20 to April 8, 2020. To evaluate the effect of hormone therapy on clinical outcomes among women, subgroup analyses using age-matched case-control data were performed. Results: Coronavirus disease 2019 was most prevalent in women in the 20-39 years age group (1,250 [44.14%]). Men were more likely to receive oxygen therapy (144 [6.46%] vs 131 [4.63%], P = 0.004), be admitted to the intensive care unit (60 [2.69%] vs 53 [1.87%], P = 0.049), and have a longer length of stay after admission to the intensive care unit (19.70 ± 11.80 vs 14.75 ± 9.23, P = 0.016). However, there was no significant difference in the mortality rate (men vs women: 42 [1.88%] vs 42 [1.48%], P = 0.267). In the multivariable Cox analysis, older age and underlying comorbidities, but not sex, were independent risk factors for mortality. Hormone therapy was not significantly associated with clinical outcomes. Conclusions: This study, using nationwide data, suggests that female sex hormones are not associated with the morbidity and clinical outcomes of coronavirus disease 2019 in South Korea.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherLippincott-Raven Publishers-
dc.relation.isPartOfMENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHCOVID-19 / epidemiology*-
dc.subject.MESHCOVID-19 / metabolism*-
dc.subject.MESHCOVID-19 Testing / statistics & numerical data*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHGonadal Steroid Hormones / metabolism*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSARS-CoV-2 / metabolism-
dc.subject.MESHYoung Adult-
dc.titleEffect of sex hormones on coronavirus disease 2019: an analysis of 5,061 laboratory-confirmed cases in South Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorYong Chan Kim-
dc.contributor.googleauthorSi Hyun Cho-
dc.contributor.googleauthorJinae Lee-
dc.contributor.googleauthorSeng Chan You-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorYoung Bin Won-
dc.contributor.googleauthorYoung Sik Choi-
dc.contributor.googleauthorYun Soo Park-
dc.identifier.doi10.1097/GME.0000000000001657-
dc.contributor.localIdA00752-
dc.contributor.localIdA01598-
dc.contributor.localIdA01598-
dc.contributor.localIdA02037-
dc.contributor.localIdA02037-
dc.contributor.localIdA04636-
dc.contributor.localIdA04636-
dc.contributor.localIdA03846-
dc.contributor.localIdA03846-
dc.relation.journalcodeJ02219-
dc.identifier.eissn1530-0374-
dc.identifier.pmid33003134-
dc.contributor.alternativeNameKim, Yong Chan-
dc.contributor.affiliatedAuthor김용찬-
dc.contributor.affiliatedAuthor박윤수-
dc.contributor.affiliatedAuthor박윤수-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor이재훈-
dc.contributor.affiliatedAuthor이재훈-
dc.contributor.affiliatedAuthor조시현-
dc.contributor.affiliatedAuthor조시현-
dc.citation.volume27-
dc.citation.number12-
dc.citation.startPage1376-
dc.citation.endPage1381-
dc.identifier.bibliographicCitationMENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, Vol.27(12) : 1376-1381, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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