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Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats

 So-Hye Hong  ;  Seung Hee Lee  ;  Jun-Young Yang  ;  Jin Hee Lee  ;  Ki Kyung Jung  ;  Ji Hyun Seok  ;  Sung-Hee Kim  ;  Ki Taek Nam  ;  Jayoung Jeong  ;  Jong Kwon Lee  ;  Jae-Ho Oh 
 TOXICS, Vol.8(3) : 54, 2020-09 
Journal Title
Issue Date
F-53B ; subchronic oral toxicity ; thyroid dysfunction ; thyroid hormone
The compound 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), a replacement for perfluorooctanesulfonate (PFOS) in the electroplating industry, has been widely detected in numerous environmental matrices, human sera, and organisms. Due to regulations that limit PFOS use, F-53B use is expected to increase. Therefore, in this study, we performed a subchronic oral toxicity study of F-53B in Sprague Dawley (SD) rats. F-53B was administered orally once daily to male and female rats for 28 days at doses of 5, 20, and 100 mg/kg/day. There were no toxicologically significant changes in F-53B-treated rats, except in the thyroid gland. However, F-53B slightly reduced the serum concentrations of thyroid hormones, including triiodothyronine and thyroxine, compared with their concentrations in the vehicle group. F-53B also induced follicular hyperplasia and was associated with increased thyroid hormone biosynthesis-associated protein expression. These results demonstrate that F-53B is a strong regulator of thyroid hormones in SD rats as it disrupts thyroid function. Thus, caution should be exercised in the industrial application of F-53B as an alternative for PFOS.
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1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Sung-Hee(김성희)
Nam, Ki Taek(남기택)
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