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Loss of Heterozygosity at Chromosome 16q Is a Negative Prognostic Factor in Korean Pediatric Patients with Favorable Histology Wilms Tumor: A Report of the Korean Pediatric Hematology Oncology Group (K-PHOG)

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dc.contributor.author유철주-
dc.contributor.author한정우-
dc.contributor.author한승민-
dc.date.accessioned2021-01-19T08:00:51Z-
dc.date.available2021-01-19T08:00:51Z-
dc.date.issued2020-04-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181425-
dc.description.abstractPurpose: Loss of heterozygosity (LOH) at chromosomes 1p and 16q is a poor prognostic factor in favorable histology Wilms tumor (FHWT). This study investigated the prevalence of LOH at 1p and 16q and evaluated its prognostic value in Korean children with FHWT. Materials and methods: We analyzed 101 FHWT patients who were diagnosed between 1996 and 2016 in Korean Society of Pediatric Hematology Oncology Group hospitals. Using paraffin-embedded kidney tissue samples sent from each center, we reviewed LOH at 1p and 16q in each patient and assessed the prognostic value of LOH status for clinical parameters affecting event-free survival (EFS). Results: Of the 101 patients, 12 (11.9%) experienced recurrence; the 3-year EFS was 87.6%. LOH at 1p or 16q was detected in 19 patients (18.8%), with five having LOH at both 1q and 16q. The frequency of LOH at 1p was higher among younger patients (p=0.049), but there was no difference in LOH prevalence according to tumor stage. In the multivariate analysis, LOH at 16q was a significant negative prognostic factor affecting EFS (3-year EFS, 73.7% vs. 91.1%; hazard ratio, 3.95; p=0.037), whereas LOH at 1p was not (p=0.786). Conclusion: LOH at 16q was a significant negative prognostic factor affecting outcome in Korean pediatric FHWT patients. Due to the small sample size of this study, large-scale multicenter trials are warranted to investigate the prognostic value of LOH at 1p and 16q in Korean children with FHWT.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHChromosomes, Human, Pair 16 / genetics*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHLoss of Heterozygosity-
dc.subject.MESHMale-
dc.subject.MESHPrognosis-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHWilms Tumor / genetics*-
dc.subject.MESHWilms Tumor / metabolism-
dc.subject.MESHWilms Tumor / mortality-
dc.titleLoss of Heterozygosity at Chromosome 16q Is a Negative Prognostic Factor in Korean Pediatric Patients with Favorable Histology Wilms Tumor: A Report of the Korean Pediatric Hematology Oncology Group (K-PHOG)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.department;Dept. of Pediatrics (소아과학교실)-
dc.contributor.googleauthorJun Eun Park-
dc.contributor.googleauthorO Kyu Noh-
dc.contributor.googleauthorYonghee Lee-
dc.contributor.googleauthorHyoung Soo Choi-
dc.contributor.googleauthorJung Woo Han-
dc.contributor.googleauthorSeung Min Hahn-
dc.contributor.googleauthorChuhl Joo Lyu-
dc.contributor.googleauthorJi Won Lee-
dc.contributor.googleauthorKeon Hee Yoo-
dc.contributor.googleauthorHong Hoe Koo-
dc.contributor.googleauthorSeon-Yong Jeong-
dc.contributor.googleauthorKi Woong Sung-
dc.identifier.doi10.4143/crt.2019.313-
dc.contributor.localIdA02524-
dc.contributor.localIdA04325-
dc.contributor.localIdA04325-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid31505910-
dc.subject.keyword16q-
dc.subject.keyword1p-
dc.subject.keywordLoss of heterozygosity-
dc.subject.keywordPrognosis-
dc.subject.keywordSurvival-
dc.subject.keywordWilms tumor-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.affiliatedAuthor유철주-
dc.contributor.affiliatedAuthor한정우-
dc.contributor.affiliatedAuthor한정우-
dc.citation.volume52-
dc.citation.number2-
dc.citation.startPage438-
dc.citation.endPage445-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.52(2) : 438-445, 2020-04-
dc.identifier.rimsid67513-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers

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