Cited 22 times in
Atherogenic index of plasma and the risk of advanced subclinical coronary artery disease beyond traditional risk factors: An observational cohort study
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2021-01-19T08:00:12Z | - |
dc.date.available | 2021-01-19T08:00:12Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 0160-9289 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/181417 | - |
dc.description.abstract | Background: Atherogenic lipoprotein profile of plasma is an important risk factor for atherosclerosis. The atherogenic index of plasma (AIP) has been suggested as a novel marker for atherosclerosis. Hypothesis: AIP is a useful marker of advanced subclinical coronary artery disease (CAD) in subjects without overt renal dysfunction. Methods: A total of 6928 subjects with estimated glomerular filtration rate > 60 mL/minutes/1.73 m2 evaluated by coronary computed tomography angiography (CCTA) for health check-up were included. The relation of AIP to advanced CAD (heavy coronary calcification, defined as coronary artery calcium score [CACS] >100 or obstructive coronary plaque [OCP], defined as plaque with >50% stenosis) was evaluated. Results: All participants were stratified into four groups based on AIP quartiles. The prevalence of CACS >100 (group I [lowest] 4.7% vs group II 7.0% vs group III 8.8% vs group IV 10.0%) and OCP (group I 3.7% vs group II 6.4% vs group III 8.8% vs group IV 10.9%) (all P < .001) increased with elevating AIP quartiles. Higher AIP (per 0.1 unit increase) was associated with an increased risk of CACS >100 (odds ratio [OR] 1.057, 95% confidence interval (CI) 1.010 to 1.106, P = .017; relative risk (RR) 1.048, 95% CI 1.009-1.089, and P = .015) and OCP (OR 1.079, 95% CI 1.033-1.127, P = .001; RR 1.069, 95% CI 1.031-1.108, P < .001) after adjusting for age > 60 years, male sex, hypertension, diabetes mellitus, dyslipidaemia, obesity, and proteinuria. Conclusion: AIP is independently associated with advanced subclinical CAD beyond traditional risk factors. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | John Wiley & Sons, Inc. | - |
dc.relation.isPartOf | CLINICAL CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Atherogenic index of plasma and the risk of advanced subclinical coronary artery disease beyond traditional risk factors: An observational cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ki-Bum Won | - |
dc.contributor.googleauthor | Mi-Hee Jang | - |
dc.contributor.googleauthor | Eun Ji Park | - |
dc.contributor.googleauthor | Hyung-Bok Park | - |
dc.contributor.googleauthor | Ran Heo | - |
dc.contributor.googleauthor | Donghee Han | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.identifier.doi | 10.1002/clc.23450 | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J00565 | - |
dc.identifier.eissn | 1932-8737 | - |
dc.identifier.pmid | 32815171 | - |
dc.subject.keyword | atherogenic index of plasma | - |
dc.subject.keyword | atherosclerosis | - |
dc.subject.keyword | coronary computed tomography angiography | - |
dc.subject.keyword | risk assessment | - |
dc.subject.keyword | serum marker | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | 장혁재 | - |
dc.citation.volume | 43 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1398 | - |
dc.citation.endPage | 1404 | - |
dc.identifier.bibliographicCitation | CLINICAL CARDIOLOGY, Vol.43(12) : 1398-1404, 2020-12 | - |
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