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Atherogenic index of plasma and the risk of advanced subclinical coronary artery disease beyond traditional risk factors: An observational cohort study

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dc.contributor.author장혁재-
dc.date.accessioned2021-01-19T08:00:12Z-
dc.date.available2021-01-19T08:00:12Z-
dc.date.issued2020-12-
dc.identifier.issn0160-9289-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181417-
dc.description.abstractBackground: Atherogenic lipoprotein profile of plasma is an important risk factor for atherosclerosis. The atherogenic index of plasma (AIP) has been suggested as a novel marker for atherosclerosis. Hypothesis: AIP is a useful marker of advanced subclinical coronary artery disease (CAD) in subjects without overt renal dysfunction. Methods: A total of 6928 subjects with estimated glomerular filtration rate > 60 mL/minutes/1.73 m2 evaluated by coronary computed tomography angiography (CCTA) for health check-up were included. The relation of AIP to advanced CAD (heavy coronary calcification, defined as coronary artery calcium score [CACS] >100 or obstructive coronary plaque [OCP], defined as plaque with >50% stenosis) was evaluated. Results: All participants were stratified into four groups based on AIP quartiles. The prevalence of CACS >100 (group I [lowest] 4.7% vs group II 7.0% vs group III 8.8% vs group IV 10.0%) and OCP (group I 3.7% vs group II 6.4% vs group III 8.8% vs group IV 10.9%) (all P < .001) increased with elevating AIP quartiles. Higher AIP (per 0.1 unit increase) was associated with an increased risk of CACS >100 (odds ratio [OR] 1.057, 95% confidence interval (CI) 1.010 to 1.106, P = .017; relative risk (RR) 1.048, 95% CI 1.009-1.089, and P = .015) and OCP (OR 1.079, 95% CI 1.033-1.127, P = .001; RR 1.069, 95% CI 1.031-1.108, P < .001) after adjusting for age > 60 years, male sex, hypertension, diabetes mellitus, dyslipidaemia, obesity, and proteinuria. Conclusion: AIP is independently associated with advanced subclinical CAD beyond traditional risk factors.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherJohn Wiley & Sons, Inc.-
dc.relation.isPartOfCLINICAL CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAtherogenic index of plasma and the risk of advanced subclinical coronary artery disease beyond traditional risk factors: An observational cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorKi-Bum Won-
dc.contributor.googleauthorMi-Hee Jang-
dc.contributor.googleauthorEun Ji Park-
dc.contributor.googleauthorHyung-Bok Park-
dc.contributor.googleauthorRan Heo-
dc.contributor.googleauthorDonghee Han-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.identifier.doi10.1002/clc.23450-
dc.contributor.localIdA03490-
dc.relation.journalcodeJ00565-
dc.identifier.eissn1932-8737-
dc.identifier.pmid32815171-
dc.subject.keywordatherogenic index of plasma-
dc.subject.keywordatherosclerosis-
dc.subject.keywordcoronary computed tomography angiography-
dc.subject.keywordrisk assessment-
dc.subject.keywordserum marker-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.affiliatedAuthor장혁재-
dc.citation.volume43-
dc.citation.number12-
dc.citation.startPage1398-
dc.citation.endPage1404-
dc.identifier.bibliographicCitationCLINICAL CARDIOLOGY, Vol.43(12) : 1398-1404, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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