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Effects of BMI and LDL-cholesterol change pattern on cardiovascular disease in normal adults and diabetics

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dc.contributor.author박은철-
dc.date.accessioned2021-01-19T07:58:52Z-
dc.date.available2021-01-19T07:58:52Z-
dc.date.issued2020-12-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181403-
dc.description.abstractIntroduction: To examine how the risk of cardiovascular disease changes according to degree of change in body mass index (BMI) and low-density lipoprotein (LDL)-cholesterol in patients with diabetes using the health medical examination cohort database of the National Health Insurance Service in Korea. In comparison, the pattern in a non-diabetic control group was also examined. Research design and methods: The study samples were 13 800 patients with type 2 diabetes and 185 898 non-diabetic controls, and their baseline characteristics and repeatedly measured BMI and LDL-cholesterol until occurrence of cardiovascular disease were collected in longitudinal data. We used the variability model that is joint of mixed effects and regression model, then estimated parameters about variability by Bayesian methods. Results: The risk of cardiovascular disease was increased significantly with high average real variability (ARV) of BMI in the patients with diabetes, but the risk of cardiovascular disease was not increased according to degree of ARV in non-diabetic controls. The Bayesian variability model was used to analyze the effects of BMI and LDL-cholesterol change pattern on development of cardiovascular disease in diabetics, showing that variability did not have a statistically significant effect on cardiovascular disease. This shows the danger of the former simple method when interpreting only the mean of the absolute value of the variation. Conclusions: The approach of simple SD in previous studies for estimation of individual variability does not consider the order of observation. However, the Bayesian method used in this study allows for flexible modeling by superimposing volatility assessments on multistage models.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBMJ in partnership with the American Diabetes Association-
dc.relation.isPartOfBMJ OPEN DIABETES RESEARCH & CARE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffects of BMI and LDL-cholesterol change pattern on cardiovascular disease in normal adults and diabetics-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine and Public Health (예방의학교실)-
dc.contributor.googleauthorTae Mi Youk-
dc.contributor.googleauthorMin Jin Kang-
dc.contributor.googleauthorSun Ok Song-
dc.contributor.googleauthorEun-Cheol Park-
dc.identifier.doi10.1136/bmjdrc-2020-001340-
dc.contributor.localIdA01618-
dc.relation.journalcodeJ03855-
dc.identifier.eissn2052-4897-
dc.identifier.pmid33355207-
dc.subject.keywordbody mass index-
dc.subject.keywordcardiovascular disease risk-
dc.subject.keywordcholesterol-
dc.subject.keywordtype 2 diabetes-
dc.contributor.alternativeNamePark, Eun-Chul-
dc.contributor.affiliatedAuthor박은철-
dc.citation.volume8-
dc.citation.number2-
dc.citation.startPagee001340-
dc.identifier.bibliographicCitationBMJ OPEN DIABETES RESEARCH & CARE, Vol.8(2) : e001340, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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