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Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity

DC FieldValueLanguage
dc.contributor.author최윤락-
dc.date.accessioned2021-01-19T07:58:25Z-
dc.date.available2021-01-19T07:58:25Z-
dc.date.issued2020-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181398-
dc.description.abstractObesity-associated inflammation and loss of muscle function play critical roles in the development of osteoarthritis (OA); thus, therapies that target muscle tissue may provide novel approaches to restoring metabolic and biomechanical dysfunction associated with obesity. Follistatin (FST), a protein that binds myostatin and activin, may have the potential to enhance muscle formation while inhibiting inflammation. Here, we hypothesized that adeno-associated virus 9 (AAV9) delivery of FST enhances muscle formation and mitigates metabolic inflammation and knee OA caused by a high-fat diet in mice. AAV-mediated FST delivery exhibited decreased obesity-induced inflammatory adipokines and cytokines systemically and in the joint synovial fluid. Regardless of diet, mice receiving FST gene therapy were protected from post-traumatic OA and bone remodeling induced by joint injury. Together, these findings suggest that FST gene therapy may provide a multifactorial therapeutic approach for injury-induced OA and metabolic inflammation in obesity.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Association for the Advancement of Science-
dc.relation.isPartOfSCIENCE ADVANCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleGene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학교실)-
dc.contributor.googleauthorRuhang Tang-
dc.contributor.googleauthorNatalia S Harasymowicz-
dc.contributor.googleauthorChia-Lung Wu-
dc.contributor.googleauthorKelsey H Collins-
dc.contributor.googleauthorYun-Rak Choi-
dc.contributor.googleauthorSara J Oswald-
dc.contributor.googleauthorFarshid Guilak-
dc.identifier.doi10.1126/sciadv.aaz7492-
dc.contributor.localIdA04136-
dc.relation.journalcodeJ03735-
dc.identifier.eissn2375-2548-
dc.identifier.pmid32426485-
dc.contributor.alternativeNameChoi, Yun Rak-
dc.contributor.affiliatedAuthor최윤락-
dc.citation.volume6-
dc.citation.number19-
dc.citation.startPageeaaz7492-
dc.identifier.bibliographicCitationSCIENCE ADVANCES, Vol.6(19) : eaaz7492, 2020-05-
dc.identifier.rimsid67419-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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