Cited 6 times in
Dipstick proteinuria and cancer incidence: a nationwide population-based study
DC Field | Value | Language |
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dc.contributor.author | 최윤진 | - |
dc.date.accessioned | 2021-01-19T07:57:06Z | - |
dc.date.available | 2021-01-19T07:57:06Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1121-8428 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/181388 | - |
dc.description.abstract | Background: The association between proteinuria and malignancy has been frequently reported, but the issue is matter of controversy. Thus, in order to shed light on the association, we evaluated proteinuria as a risk factor for malignancy using the dataset from the Korean National Health Insurance System (NHIS). Methods: The subjects had undergone a medical examination in 2009 (index year) among the entire Korean adult population. From a pool of 10,505,818 participants, we excluded subjects who were younger than 19 years (15,327), had a previous diagnosis of cancer (152,095), had missing data for at least one variable (544,508), and were diagnosed with cancer within 1 year from the index year (79,501). Proteinuria was examined by a single dipstick urinalysis. Results: A total of 9,714,387 subjects were included in this study and tracked until December 31, 2017. The participants were divided into three groups; no (95.2%), trace (2.3%), and overt (2.5%) proteinuria. Over the duration of this study, we observed that overt proteinuria was associated with an increased risk of cancer development (all cancers) (adjusted HR 1.154, 95% CI 1.134-1.173) and the long-term risk of cancer incidence increased proportionally according to the changes in proteinuria over a four-year period. Limitations: Our study population consisted of Korean adults. Therefore, the results of this study may not be generalized to other ethnicities. Conclusions: We found a significant relationship between proteinuria and the risk of overall and site-specific cancer development. Further studies are needed to find an explanation of these findings. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | JOURNAL OF NEPHROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Dipstick proteinuria and cancer incidence: a nationwide population-based study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Shin Young Ahn | - |
dc.contributor.googleauthor | Yoon Jin Choi | - |
dc.contributor.googleauthor | Kyungdo Han | - |
dc.contributor.googleauthor | Gang Jee Ko | - |
dc.contributor.googleauthor | Young Joo Kwon | - |
dc.contributor.googleauthor | Yong-Gyu Park | - |
dc.identifier.doi | 10.1007/s40620-020-00740-1 | - |
dc.contributor.localId | A05984 | - |
dc.relation.journalcode | J01616 | - |
dc.identifier.eissn | 1724-6059 | - |
dc.identifier.pmid | 32335824 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s40620-020-00740-1 | - |
dc.subject.keyword | Cancer incidence | - |
dc.subject.keyword | Dipstick proteinuria | - |
dc.subject.keyword | Nationwide database | - |
dc.subject.keyword | Risk | - |
dc.contributor.alternativeName | Choi, Yoon Jin | - |
dc.contributor.affiliatedAuthor | 최윤진 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1067 | - |
dc.citation.endPage | 1077 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEPHROLOGY, Vol.33(5) : 1067-1077, 2020-10 | - |
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