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Dipstick proteinuria and cancer incidence: a nationwide population-based study

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dc.contributor.author최윤진-
dc.date.accessioned2021-01-19T07:57:06Z-
dc.date.available2021-01-19T07:57:06Z-
dc.date.issued2020-10-
dc.identifier.issn1121-8428-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181388-
dc.description.abstractBackground: The association between proteinuria and malignancy has been frequently reported, but the issue is matter of controversy. Thus, in order to shed light on the association, we evaluated proteinuria as a risk factor for malignancy using the dataset from the Korean National Health Insurance System (NHIS). Methods: The subjects had undergone a medical examination in 2009 (index year) among the entire Korean adult population. From a pool of 10,505,818 participants, we excluded subjects who were younger than 19 years (15,327), had a previous diagnosis of cancer (152,095), had missing data for at least one variable (544,508), and were diagnosed with cancer within 1 year from the index year (79,501). Proteinuria was examined by a single dipstick urinalysis. Results: A total of 9,714,387 subjects were included in this study and tracked until December 31, 2017. The participants were divided into three groups; no (95.2%), trace (2.3%), and overt (2.5%) proteinuria. Over the duration of this study, we observed that overt proteinuria was associated with an increased risk of cancer development (all cancers) (adjusted HR 1.154, 95% CI 1.134-1.173) and the long-term risk of cancer incidence increased proportionally according to the changes in proteinuria over a four-year period. Limitations: Our study population consisted of Korean adults. Therefore, the results of this study may not be generalized to other ethnicities. Conclusions: We found a significant relationship between proteinuria and the risk of overall and site-specific cancer development. Further studies are needed to find an explanation of these findings.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfJOURNAL OF NEPHROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDipstick proteinuria and cancer incidence: a nationwide population-based study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorShin Young Ahn-
dc.contributor.googleauthorYoon Jin Choi-
dc.contributor.googleauthorKyungdo Han-
dc.contributor.googleauthorGang Jee Ko-
dc.contributor.googleauthorYoung Joo Kwon-
dc.contributor.googleauthorYong-Gyu Park-
dc.identifier.doi10.1007/s40620-020-00740-1-
dc.contributor.localIdA05984-
dc.relation.journalcodeJ01616-
dc.identifier.eissn1724-6059-
dc.identifier.pmid32335824-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s40620-020-00740-1-
dc.subject.keywordCancer incidence-
dc.subject.keywordDipstick proteinuria-
dc.subject.keywordNationwide database-
dc.subject.keywordRisk-
dc.contributor.alternativeNameChoi, Yoon Jin-
dc.contributor.affiliatedAuthor최윤진-
dc.citation.volume33-
dc.citation.number5-
dc.citation.startPage1067-
dc.citation.endPage1077-
dc.identifier.bibliographicCitationJOURNAL OF NEPHROLOGY, Vol.33(5) : 1067-1077, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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