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아토피피부염 환자에서 Zinc-alpha-2 Glycoprotein 함유 보습 제품의 치료 효능

DC FieldValueLanguage
dc.contributor.author곡원호-
dc.contributor.author박창욱-
dc.contributor.author이광훈-
dc.date.accessioned2021-01-19T07:56:04Z-
dc.date.available2021-01-19T07:56:04Z-
dc.date.issued2020-11-
dc.identifier.issn0494-4739-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181383-
dc.description.abstractBackground: Patients with atopic dermatitis (AD) are vulnerable to xerosis due to impaired skin barrier function, which makes moisturizing essential. Recently, zinc-alpha-2 glycoprotein (ZAG) has appeared to modulate the skin barrier function in AD, and has been proposed as a potential therapeutic molecule in AD. Objective: This study aimed to evaluate the effects of a ZAG-containing moisturizer on restoration of the skin barrier and clinical improvement of AD. Methods: In this randomized, double-blind study, 42 patients (average age, 26.5 years) with mild-to-moderate AD were enrolled. The subjects were divided into two groups, ZAG-containing moisturizer or control, in which the intervention or control were applied twice a day for 4 weeks. The primary outcome was a change in the eczema area and severity index (EASI) after 4 weeks, and the secondary outcome included the transepidermal water loss (TEWL), corneometer, visual assessment score (VAS) for pruritus and sleep disturbance, and investigator’s global assessment (IGA). Results: ZAG-containing moisturizer was well-tolerated, with a significant decrease in the EASI score compared to the control group after 4 weeks of application (p<0.05). As objective assessments of skin barrier function, TEWL also showed a significant, rapid decrease in the ZAG group compared to the control group after 2 weeks of application (p<0.05). A significant improvement in AD symptoms was observed at 4 weeks, such as the VAS score for pruritus and sleep disturbance, and IGA. Conclusion: The moisturizer containing ZAG (By the doctor Ato repair creamⓇ, Whitecospharm, Korea) effectively restored the function of the skin barrier, which led to a relief in the signs and symptoms of AD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageKorean-
dc.publisher대한피부과학회-
dc.relation.isPartOfKorean Journal of Dermatology (대한피부과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title아토피피부염 환자에서 Zinc-alpha-2 Glycoprotein 함유 보습 제품의 치료 효능-
dc.title.alternativeThe Efficacy and Safety of Zinc-alpha-2 Glycoprotein (ZAG) Containing Moisturizer in Atopic Dermatitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학교실)-
dc.contributor.googleauthor김수민-
dc.contributor.googleauthor곡원호-
dc.contributor.googleauthor이광훈-
dc.contributor.googleauthor박창욱-
dc.contributor.localIdA04510-
dc.contributor.localIdA01716-
dc.contributor.localIdA01716-
dc.contributor.localIdA02674-
dc.contributor.localIdA02674-
dc.relation.journalcodeJ02000-
dc.identifier.urlhttp://kiss.kstudy.com/thesis/thesis-view.asp?key=3835276-
dc.subject.keywordAtopic dermatitis-
dc.subject.keywordMoisturizer-
dc.subject.keywordSkin barrier-
dc.subject.keywordZinc-alpha-2 glycoprotein-
dc.contributor.alternativeNameChu, Howard-
dc.contributor.affiliatedAuthor곡원호-
dc.contributor.affiliatedAuthor박창욱-
dc.contributor.affiliatedAuthor박창욱-
dc.contributor.affiliatedAuthor이광훈-
dc.contributor.affiliatedAuthor이광훈-
dc.citation.volume58-
dc.citation.number9-
dc.citation.startPage575-
dc.citation.endPage582-
dc.identifier.bibliographicCitationKorean Journal of Dermatology (대한피부과학회지), Vol.58(9) : 575-582, 2020-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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