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아토피피부염 환자에서 Zinc-alpha-2 Glycoprotein 함유 보습 제품의 치료 효능
DC Field | Value | Language |
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dc.contributor.author | 곡원호 | - |
dc.contributor.author | 박창욱 | - |
dc.contributor.author | 이광훈 | - |
dc.date.accessioned | 2021-01-19T07:56:04Z | - |
dc.date.available | 2021-01-19T07:56:04Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 0494-4739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/181383 | - |
dc.description.abstract | Background: Patients with atopic dermatitis (AD) are vulnerable to xerosis due to impaired skin barrier function, which makes moisturizing essential. Recently, zinc-alpha-2 glycoprotein (ZAG) has appeared to modulate the skin barrier function in AD, and has been proposed as a potential therapeutic molecule in AD. Objective: This study aimed to evaluate the effects of a ZAG-containing moisturizer on restoration of the skin barrier and clinical improvement of AD. Methods: In this randomized, double-blind study, 42 patients (average age, 26.5 years) with mild-to-moderate AD were enrolled. The subjects were divided into two groups, ZAG-containing moisturizer or control, in which the intervention or control were applied twice a day for 4 weeks. The primary outcome was a change in the eczema area and severity index (EASI) after 4 weeks, and the secondary outcome included the transepidermal water loss (TEWL), corneometer, visual assessment score (VAS) for pruritus and sleep disturbance, and investigator’s global assessment (IGA). Results: ZAG-containing moisturizer was well-tolerated, with a significant decrease in the EASI score compared to the control group after 4 weeks of application (p<0.05). As objective assessments of skin barrier function, TEWL also showed a significant, rapid decrease in the ZAG group compared to the control group after 2 weeks of application (p<0.05). A significant improvement in AD symptoms was observed at 4 weeks, such as the VAS score for pruritus and sleep disturbance, and IGA. Conclusion: The moisturizer containing ZAG (By the doctor Ato repair creamⓇ, Whitecospharm, Korea) effectively restored the function of the skin barrier, which led to a relief in the signs and symptoms of AD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | Korean | - |
dc.publisher | 대한피부과학회 | - |
dc.relation.isPartOf | Korean Journal of Dermatology (대한피부과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 아토피피부염 환자에서 Zinc-alpha-2 Glycoprotein 함유 보습 제품의 치료 효능 | - |
dc.title.alternative | The Efficacy and Safety of Zinc-alpha-2 Glycoprotein (ZAG) Containing Moisturizer in Atopic Dermatitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | 김수민 | - |
dc.contributor.googleauthor | 곡원호 | - |
dc.contributor.googleauthor | 이광훈 | - |
dc.contributor.googleauthor | 박창욱 | - |
dc.contributor.localId | A04510 | - |
dc.contributor.localId | A01716 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J02000 | - |
dc.identifier.url | http://kiss.kstudy.com/thesis/thesis-view.asp?key=3835276 | - |
dc.subject.keyword | Atopic dermatitis | - |
dc.subject.keyword | Moisturizer | - |
dc.subject.keyword | Skin barrier | - |
dc.subject.keyword | Zinc-alpha-2 glycoprotein | - |
dc.contributor.alternativeName | Chu, Howard | - |
dc.contributor.affiliatedAuthor | 곡원호 | - |
dc.contributor.affiliatedAuthor | 박창욱 | - |
dc.contributor.affiliatedAuthor | 이광훈 | - |
dc.citation.volume | 58 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 575 | - |
dc.citation.endPage | 582 | - |
dc.identifier.bibliographicCitation | Korean Journal of Dermatology (대한피부과학회지), Vol.58(9) : 575-582, 2020-11 | - |
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