Cited 32 times in
TGF-β Pathway in Salivary Gland Fibrosis
DC Field | Value | Language |
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dc.contributor.author | 김현실 | - |
dc.contributor.author | 육종인 | - |
dc.contributor.author | 장향란 | - |
dc.contributor.author | 조은애산드라 | - |
dc.date.accessioned | 2021-01-19T07:54:36Z | - |
dc.date.available | 2021-01-19T07:54:36Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/181374 | - |
dc.description.abstract | Fibrosis is presented in various physiologic and pathologic conditions of the salivary gland. Transforming growth factor beta (TGF-β) pathway has a pivotal role in the pathogenesis of fibrosis in several organs, including the salivary glands. Among the TGF-β superfamily members, TGF-β1 and 2 are pro-fibrotic ligands, whereas TGF-β3 and some bone morphogenetic proteins (BMPs) are anti-fibrotic ligands. TGF-β1 is thought to be associated with the pro-fibrotic pathogenesis of sialadenitis, post-radiation salivary gland dysfunction, and Sjögren's syndrome. Potential therapeutic strategies that target multiple levels in the TGF-β pathway are under preclinical and clinical research for fibrosis. Despite the anti-fibrotic effect of BMPs, their in vivo delivery poses a challenge in terms of adequate clinical efficacy. In this article, we will review the relevance of TGF-β signaling in salivary gland fibrosis and advances of potential therapeutic options in the field. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | TGF-β Pathway in Salivary Gland Fibrosis | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학교실) | - |
dc.contributor.googleauthor | Xianglan Zhang | - |
dc.contributor.googleauthor | Jun Seop Yun | - |
dc.contributor.googleauthor | Dawool Han | - |
dc.contributor.googleauthor | Jong In Yook | - |
dc.contributor.googleauthor | Hyun Sil Kim | - |
dc.contributor.googleauthor | Eunae Sandra Cho | - |
dc.identifier.doi | 10.3390/ijms21239138 | - |
dc.contributor.localId | A01121 | - |
dc.contributor.localId | A02536 | - |
dc.contributor.localId | A03489 | - |
dc.contributor.localId | A04799 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 33266300 | - |
dc.subject.keyword | BMP | - |
dc.subject.keyword | Sjögren’s syndrome | - |
dc.subject.keyword | TGF-β | - |
dc.subject.keyword | drug delivery | - |
dc.subject.keyword | fibrosis | - |
dc.subject.keyword | salivary gland | - |
dc.subject.keyword | sialadenitis | - |
dc.contributor.alternativeName | Kim, Hyun Sil | - |
dc.contributor.affiliatedAuthor | 김현실 | - |
dc.contributor.affiliatedAuthor | 육종인 | - |
dc.contributor.affiliatedAuthor | 장향란 | - |
dc.contributor.affiliatedAuthor | 조은애산드라 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 9138 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(23) : 9138, 2020-11 | - |
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