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TGF-β Pathway in Salivary Gland Fibrosis

DC FieldValueLanguage
dc.contributor.author김현실-
dc.contributor.author육종인-
dc.contributor.author장향란-
dc.contributor.author조은애산드라-
dc.date.accessioned2021-01-19T07:54:36Z-
dc.date.available2021-01-19T07:54:36Z-
dc.date.issued2020-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181374-
dc.description.abstractFibrosis is presented in various physiologic and pathologic conditions of the salivary gland. Transforming growth factor beta (TGF-β) pathway has a pivotal role in the pathogenesis of fibrosis in several organs, including the salivary glands. Among the TGF-β superfamily members, TGF-β1 and 2 are pro-fibrotic ligands, whereas TGF-β3 and some bone morphogenetic proteins (BMPs) are anti-fibrotic ligands. TGF-β1 is thought to be associated with the pro-fibrotic pathogenesis of sialadenitis, post-radiation salivary gland dysfunction, and Sjögren's syndrome. Potential therapeutic strategies that target multiple levels in the TGF-β pathway are under preclinical and clinical research for fibrosis. Despite the anti-fibrotic effect of BMPs, their in vivo delivery poses a challenge in terms of adequate clinical efficacy. In this article, we will review the relevance of TGF-β signaling in salivary gland fibrosis and advances of potential therapeutic options in the field.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleTGF-β Pathway in Salivary Gland Fibrosis-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Pathology (구강병리학교실)-
dc.contributor.googleauthorXianglan Zhang-
dc.contributor.googleauthorJun Seop Yun-
dc.contributor.googleauthorDawool Han-
dc.contributor.googleauthorJong In Yook-
dc.contributor.googleauthorHyun Sil Kim-
dc.contributor.googleauthorEunae Sandra Cho-
dc.identifier.doi10.3390/ijms21239138-
dc.contributor.localIdA01121-
dc.contributor.localIdA02536-
dc.contributor.localIdA02536-
dc.contributor.localIdA03489-
dc.contributor.localIdA03489-
dc.contributor.localIdA04799-
dc.contributor.localIdA04799-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid33266300-
dc.subject.keywordBMP-
dc.subject.keywordSjögren’s syndrome-
dc.subject.keywordTGF-β-
dc.subject.keyworddrug delivery-
dc.subject.keywordfibrosis-
dc.subject.keywordsalivary gland-
dc.subject.keywordsialadenitis-
dc.contributor.alternativeNameKim, Hyun Sil-
dc.contributor.affiliatedAuthor김현실-
dc.contributor.affiliatedAuthor육종인-
dc.contributor.affiliatedAuthor육종인-
dc.contributor.affiliatedAuthor장향란-
dc.contributor.affiliatedAuthor장향란-
dc.contributor.affiliatedAuthor조은애산드라-
dc.contributor.affiliatedAuthor조은애산드라-
dc.citation.volume21-
dc.citation.number23-
dc.citation.startPage9138-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(23) : 9138, 2020-11-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers

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