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Visceral Adiposity as a Significant Predictor of Sunitinib-Induced Dose-Limiting Toxicities and Survival in Patients with Metastatic Clear Cell Renal Cell Carcinoma

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dc.contributor.author구교철-
dc.contributor.author나군호-
dc.contributor.author박지수-
dc.contributor.author함원식-
dc.date.accessioned2021-01-19T07:51:32Z-
dc.date.available2021-01-19T07:51:32Z-
dc.date.issued2020-12-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181352-
dc.description.abstractSunitinib is a first-line treatment for metastatic renal cell carcinoma (mRCC). Little is known about the predictive factors of sunitinib-induced dose-limiting toxicity (DLT) in Asian populations. We investigated whether body composition predicts sunitinib-induced DLT. We retrospectively reviewed sunitinib-treated Korean patients with clear cell mRCC from eight institutions. Body composition was measured using computed tomography. DLT was defined as any adverse event leading to dose reduction or treatment discontinuation. Univariate analysis was used to compare body composition indices, and logistic regression analyses were performed for factors predicting early DLT. Overall, 111/311 (32.5%) of patients experienced DLT. Significant differences were observed in the subcutaneous adipose tissue index (SATI; p = 0.001) and visceral adipose tissue index (VATI; p < 0.001) between patients with and without DLT. Multivariate analyses revealed that VATI (odds ratio: 1.013; p = 0.029) was significantly associated with early DLT. Additionally, 20% of patients who had a body mass index (BMI) greater than 23 kg/m2 and a low VATI experienced DLT, whereas 34.3% of the remaining groups had DLT (p = 0.034). Significant differences were observed for median progression-free survival (13.0 vs. 26.0 months, respectively; p = 0.006) between patients with low and high VATI. Visceral adiposity was a significant predictor of sunitinib-associated DLT and survival. Patients with a low VATI and a BMI greater than 23 kg/m2 experienced lower DLTs.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleVisceral Adiposity as a Significant Predictor of Sunitinib-Induced Dose-Limiting Toxicities and Survival in Patients with Metastatic Clear Cell Renal Cell Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨의학교실)-
dc.contributor.googleauthorJee Soo Park-
dc.contributor.googleauthorKyo Chul Koo-
dc.contributor.googleauthorDoo Yong Chung-
dc.contributor.googleauthorSun Il Kim-
dc.contributor.googleauthorJeongho Kim-
dc.contributor.googleauthorCheol Kyu Oh-
dc.contributor.googleauthorTae Nam Kim-
dc.contributor.googleauthorSung Ku Kang-
dc.contributor.googleauthorJae Won Park-
dc.contributor.googleauthorYoung Eun Yoon-
dc.contributor.googleauthorSung Yul Park-
dc.contributor.googleauthorKoon Ho Rha-
dc.contributor.googleauthorWon Sik Ham-
dc.identifier.doi10.3390/cancers12123602-
dc.contributor.localIdA00188-
dc.contributor.localIdA01227-
dc.contributor.localIdA01227-
dc.contributor.localIdA05336-
dc.contributor.localIdA05336-
dc.contributor.localIdA04337-
dc.contributor.localIdA04337-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.identifier.pmid33276522-
dc.subject.keyworddose-limiting toxicity-
dc.subject.keywordobesity-
dc.subject.keywordrenal cell carcinoma-
dc.subject.keywordsunitinib-
dc.subject.keywordvisceral adiposity-
dc.contributor.alternativeNameKoo, Kyo Chul-
dc.contributor.affiliatedAuthor구교철-
dc.contributor.affiliatedAuthor나군호-
dc.contributor.affiliatedAuthor나군호-
dc.contributor.affiliatedAuthor박지수-
dc.contributor.affiliatedAuthor박지수-
dc.contributor.affiliatedAuthor함원식-
dc.contributor.affiliatedAuthor함원식-
dc.citation.volume12-
dc.citation.number12-
dc.citation.startPage3602-
dc.identifier.bibliographicCitationCANCERS, Vol.12(12) : 3602, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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