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Clinical characteristics associated with drug-free sustained remission in patients with rheumatoid arthritis: Data from Korean Intensive Management of Early Rheumatoid Arthritis (KIMERA)

DC FieldValueLanguage
dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author이상원-
dc.contributor.author정승민-
dc.date.accessioned2021-01-19T07:51:18Z-
dc.date.available2021-01-19T07:51:18Z-
dc.date.issued2020-12-
dc.identifier.issn0049-0172-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181350-
dc.description.abstractObjectives: There is limited information on treatment withdrawal in patients with rheumatoid arthritis (RA). This study investigated the clinical course after stopping disease-modifying anti-rheumatic drugs (DMARDs) in patients with well-controlled RA and the clinical features associated with disease flare. Methods: Among patients in the Korean Intensive Management of Early Rheumatoid Arthritis (KIMERA) cohort, discontinuation of DMARDs was determined by a shared decision between patient and rheumatologist. Drug-free remission was defined as (1) non-use of DMARDs and corticosteroids, (2) Disease Activity Score in 28 joints (DAS28) <2.6, and (3) no evidence of synovitis. The maintenance rate of drug-free remission and the predictors for flare were evaluated using Cox proportional hazard models. Results: Of 234 patients, 50 patients discontinued DMARDs. All but one using etanercept were treated with conventional synthetic DMARDs. The median follow-up duration was 30 months, and 31 patients (62%) experienced disease flare after stopping DMARDs. The maintenance rate of drug-free remission was 94.0%, 86.7%, and 46.1% at 12, 24, and 48 months, respectively. Disease flare was correlated with longer time to remission, failure of initial DMARDs, and longer duration of disease and higher disease activity at DMARD withdrawal (P = 0.001, 0.022, 0.010 and 0.037, respectively). In multivariate analyses, longer duration of disease (>24 months) and higher disease activity (DAS28 >2.26) at DMARD withdrawal was independently associated with disease flare. Conclusion: Drug-free remission was feasible in selected patients with well-controlled RA. Patients with early RA and lower disease activity at DMARD withdrawal are more likely to maintain the drug-free remission.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherW.B. Saunders-
dc.relation.isPartOfSEMINARS IN ARTHRITIS AND RHEUMATISM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClinical characteristics associated with drug-free sustained remission in patients with rheumatoid arthritis: Data from Korean Intensive Management of Early Rheumatoid Arthritis (KIMERA)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSeung Min Jung-
dc.contributor.googleauthorJung Yoon Pyo-
dc.contributor.googleauthorSang-Won Lee-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorSoo-Kon Lee-
dc.contributor.googleauthorYong-Beom Park-
dc.identifier.doi10.1016/j.semarthrit.2020.02.014-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02057-
dc.contributor.localIdA02824-
dc.contributor.localIdA02824-
dc.contributor.localIdA05179-
dc.contributor.localIdA05179-
dc.relation.journalcodeJ02649-
dc.identifier.eissn1532-866X-
dc.identifier.pmid32241617-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0049017220300676-
dc.subject.keywordDisease activity-
dc.subject.keywordDisease duration-
dc.subject.keywordDrug-free remission-
dc.subject.keywordRheumatoid arthritis-
dc.subject.keywordTreatment withdrawal.-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor정승민-
dc.contributor.affiliatedAuthor정승민-
dc.citation.volume50-
dc.citation.number6-
dc.citation.startPage1414-
dc.citation.endPage1420-
dc.identifier.bibliographicCitationSEMINARS IN ARTHRITIS AND RHEUMATISM, Vol.50(6) : 1414-1420, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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