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The role of postoperative radiotherapy in stage II and III thymoma: a Korean multicenter database study

DC FieldValueLanguage
dc.contributor.author김대준-
dc.contributor.author박성용-
dc.contributor.author백효채-
dc.contributor.author서지원-
dc.contributor.author송승환-
dc.contributor.author이진구-
dc.contributor.author이창영-
dc.contributor.author정경영-
dc.date.accessioned2021-01-19T07:45:13Z-
dc.date.available2021-01-19T07:45:13Z-
dc.date.issued2020-11-
dc.identifier.issn2072-1439-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181319-
dc.description.abstractBackground: Complete resection is a standard treatment for patients with Masaoka-Koga stages II and III thymoma, however the role of postoperative radiotherapy (PORT) is controversial. We analyzed data collected from 4 Korean hospitals to determine the effectiveness of PORT in stage II and III thymoma patients. Methods: Between January 2000 and December 2013, 1,663 patients underwent surgery for thymic tumors at the 4 hospitals. Among them, 668 patients (527 with stage II and 141 with stage III) were investigated, among whom, 443 received PORT (335 with stage II and 108 with stage III). Propensity score matching (PSM) was performed, and 404 patients (346 with stage II and 58 with stage III) were selected. Results: Perioperative characteristics were similar in the PORT and non-PORT groups after PSM. On survival analysis of stage II patients, the PORT and non-PORT groups showed no difference in either 5-year recurrence-free survival (RFS) (96.3% vs. 96.6%, P=0.622) or 5-year overall survival (OS) (94.6% vs. 93.8%, P=0.839). However, among stage III patients, the PORT group showed significantly better 5-year RFS (75.7% vs. 50.1%, P=0.040) and 5-year OS (86.5% vs. 54.7%, P=0.001). On multivariate Cox regression analysis, PORT was a significant positive prognostic factor in terms of both RFS (P=0.005) and OS (P=0.004) in patients with stage III thymomas, but not in those with stage II disease (P=0.987 and 0.968, respectively). Conclusions: PORT improved the RFS and OS in stage III thymoma patients, but showed no survival benefit in stage II patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPioneer Bioscience Pub. Co.-
dc.relation.isPartOfJOURNAL OF THORACIC DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleThe role of postoperative radiotherapy in stage II and III thymoma: a Korean multicenter database study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)-
dc.contributor.googleauthorSeung Hwan Song-
dc.contributor.googleauthorJee Won Suh-
dc.contributor.googleauthorWoo Sik Yu-
dc.contributor.googleauthorGo Eun Byun-
dc.contributor.googleauthorSeong Yong Park-
dc.contributor.googleauthorChang Young Lee-
dc.contributor.googleauthorDae Joon Kim-
dc.contributor.googleauthorHyo Chae Paik-
dc.contributor.googleauthorKyung Young Chung-
dc.contributor.googleauthorGeun Dong Lee-
dc.contributor.googleauthorSehoon Choi-
dc.contributor.googleauthorHyeong Ryul Kim-
dc.contributor.googleauthorYong-Hee Kim-
dc.contributor.googleauthorDong Kwan Kim-
dc.contributor.googleauthorSeung-Il Park-
dc.contributor.googleauthorJong Ho Cho-
dc.contributor.googleauthorHong Kwan Kim-
dc.contributor.googleauthorYong Soo Choi-
dc.contributor.googleauthorJhingook Kim-
dc.contributor.googleauthorJae Il Zo-
dc.contributor.googleauthorYoung Mog Shim-
dc.contributor.googleauthorYoohwa Hwang-
dc.contributor.googleauthorSamina Park-
dc.contributor.googleauthorIn Kyu Park-
dc.contributor.googleauthorChang Hyun Kang-
dc.contributor.googleauthorYoung Tae Kim-
dc.contributor.googleauthorJin Gu Lee-
dc.identifier.doi10.21037/jtd-20-1713-
dc.contributor.localIdA00368-
dc.contributor.localIdA01508-
dc.contributor.localIdA01508-
dc.contributor.localIdA01846-
dc.contributor.localIdA01846-
dc.contributor.localIdA04956-
dc.contributor.localIdA04956-
dc.contributor.localIdA04963-
dc.contributor.localIdA04963-
dc.contributor.localIdA03225-
dc.contributor.localIdA03225-
dc.contributor.localIdA03245-
dc.contributor.localIdA03245-
dc.contributor.localIdA03571-
dc.contributor.localIdA03571-
dc.relation.journalcodeJ01907-
dc.identifier.eissn2077-6624-
dc.identifier.pmid33282369-
dc.subject.keywordThymoma-
dc.subject.keywordpostoperative radiotherapy (PORT)-
dc.subject.keywordstage II-
dc.subject.keywordstage III-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.affiliatedAuthor김대준-
dc.contributor.affiliatedAuthor박성용-
dc.contributor.affiliatedAuthor박성용-
dc.contributor.affiliatedAuthor백효채-
dc.contributor.affiliatedAuthor백효채-
dc.contributor.affiliatedAuthor서지원-
dc.contributor.affiliatedAuthor서지원-
dc.contributor.affiliatedAuthor송승환-
dc.contributor.affiliatedAuthor송승환-
dc.contributor.affiliatedAuthor이진구-
dc.contributor.affiliatedAuthor이진구-
dc.contributor.affiliatedAuthor이창영-
dc.contributor.affiliatedAuthor이창영-
dc.contributor.affiliatedAuthor정경영-
dc.contributor.affiliatedAuthor정경영-
dc.citation.volume12-
dc.citation.number11-
dc.citation.startPage6680-
dc.citation.endPage6689-
dc.identifier.bibliographicCitationJOURNAL OF THORACIC DISEASE, Vol.12(11) : 6680-6689, 2020-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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