0 54

Cited 0 times in

Reactive oxygen species modulator 1 expression predicts lymph node metastasis and survival in early-stage non-small cell lung cancer

DC FieldValueLanguage
dc.contributor.author박혜정-
dc.contributor.author차윤진-
dc.date.accessioned2021-01-19T07:44:06Z-
dc.date.available2021-01-19T07:44:06Z-
dc.date.issued2020-12-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181311-
dc.description.abstractReactive oxygen species modulator 1 (romo1) causes cell hyperplasia and promotes cancer cell invasion. Based recent studies, the overexpression of romo1 is associated with lymphatic metastasis and poor prognosis in lung cancer. We aimed to evaluate associations between romo1 expression and lymph node metastasis in non-small cell lung cancer (NSCLC). Clinical data and pathological results were retrospectively reviewed for 98 subjects diagnosed with NSCLC and who underwent surgical biopsy between 1994 and 2009. A total 98 tumor specimens were analyzed. The romo1 H score was correlated with stage and was significantly higher in subjects with lymph node metastasis than in those without metastasis (173 vs 116; P < 0.05). The area (%) of grade 1 expression was significantly smaller (19.5 vs 37.0; P = 0.005) and the area of grade 3 expression was significantly larger (27.9 vs 6.00; P < 0.001) in subjects with lymph node metastasis than in those without metastasis. In stage I patients, disease free survival (DFS) (191 ± 18.8 vs. 75.6 ± 22.4 months, P = 0.004) was significantly longer in the low romo1 group than in the high romo1 group. A multivariate analysis showed a significant association between high romo1 expression and poor DFS (hazard ratio 5.59, 95 confidence interval, 1.54-20.3, P = 0.009). These findings support the prognostic value of romo1 in NSCLC, especially in stage I.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung / metabolism*-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung / mortality-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung / pathology*-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms / metabolism*-
dc.subject.MESHLung Neoplasms / mortality-
dc.subject.MESHLung Neoplasms / pathology*-
dc.subject.MESHLymph Nodes / metabolism-
dc.subject.MESHLymph Nodes / pathology-
dc.subject.MESHLymphatic Metastasis / pathology*-
dc.subject.MESHMale-
dc.subject.MESHMembrane Proteins / metabolism*-
dc.subject.MESHMitochondrial Proteins / metabolism*-
dc.subject.MESHNeoplasm Staging / methods-
dc.subject.MESHPrognosis-
dc.subject.MESHReactive Oxygen Species / metabolism-
dc.titleReactive oxygen species modulator 1 expression predicts lymph node metastasis and survival in early-stage non-small cell lung cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorTaehee Kim-
dc.contributor.googleauthorYoon Jin Cha-
dc.contributor.googleauthorJi Hyun Park-
dc.contributor.googleauthorArum Kim-
dc.contributor.googleauthorYong Jun Choi-
dc.contributor.googleauthorHye Jung Park-
dc.identifier.doi10.1371/journal.pone.0239670-
dc.contributor.localIdA01769-
dc.contributor.localIdA04001-
dc.contributor.localIdA04001-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid33259495-
dc.contributor.alternativeNamePark, Hye Jung-
dc.contributor.affiliatedAuthor박혜정-
dc.contributor.affiliatedAuthor차윤진-
dc.contributor.affiliatedAuthor차윤진-
dc.citation.volume15-
dc.citation.number12-
dc.citation.startPagee239,670-
dc.identifier.bibliographicCitationPLOS ONE, Vol.15(12) : e239,670, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.