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The Effect of Conditioned Media From Human Adipocyte-Derived Mesenchymal Stem Cells on Androgenetic Alopecia After Nonablative Fractional Laser Treatment

 Young In Lee  ;  Jihee Kim  ;  Jemin Kim  ;  Sujin Park  ;  Ju Hee Lee 
 DERMATOLOGIC SURGERY, Vol.46(12) : 1698-1704, 2020-12 
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Background: The conditioned media from adipocyte-derived mesenchymal stem cells-conditioned media (ADSC-CM) contains cytokines and growth factors that stimulate hair regeneration. Objective: We evaluated the efficacy and safety of human ADSC-CM treatment on patients who underwent nonablative fractional laser for the treatment of androgenetic alopecia (AGA). Materials and methods: Thirty patients who underwent nonablative fractional laser treatment were topically administered either ADSC-CM or placebo solution. As a primary outcome, phototrichograms were taken to measure changes in hair density at each visit. In addition, global improvement scores (GISs) were compared by clinical digital photographs, which were taken at the initial and final visits, and assessed by 2 independent dermatologists. Finally, the investigator's improvement score was measured by questionnaire response during the final visit. Results: Hair density comparisons during the treatment period revealed that the ADSC-CM group had significantly higher final densities compared with the placebo group. The GIS of the ADSC-CM group was also significantly higher than the placebo group. Finally, no adverse effects associated with the application of ADSC-CM were noted during the study. Conclusion: The application of ADSC-CM after nonablative fractional laser treatment accelerated increases in hair density and volume in AGA patients.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jemin(김제민) ORCID logo https://orcid.org/0000-0001-6628-3507
Kim, Jihee(김지희) ORCID logo https://orcid.org/0000-0002-0047-5941
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
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