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Osteogenic Properties of Novel Methylsulfonylmethane-Coated Hydroxyapatite Scaffold

DC FieldValueLanguage
dc.contributor.author권재성-
dc.contributor.author김광만-
dc.date.accessioned2020-12-11T08:02:36Z-
dc.date.available2020-12-11T08:02:36Z-
dc.date.issued2020-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180750-
dc.description.abstractDespite numerous advantages of using porous hydroxyapatite (HAp) scaffolds in bone regeneration, the material is limited in terms of osteoinduction. In this study, the porous scaffold made from nanosized HAp was coated with different concentrations of osteoinductive aqueous methylsulfonylmethane (MSM) solution (2.5, 5, 10, and 20%) and the corresponding MH scaffolds were referred to as MH2.5, MH5, MH10, and MH20, respectively. The results showed that all MH scaffolds resulted in burst release of MSM for up to 7 d. Cellular experiments were conducted using MC3T3-E1 preosteoblast cells, which showed no significant difference between the MH2.5 scaffold and the control with respect to the rate of cell proliferation (p > 0.05). There was no significant difference between each group at day 4 for alkaline phosphatase (ALP) activity, though the MH2.5 group showed higher level of activity than other groups at day 10. Calcium deposition, using alizarin red staining, showed that cell mineralization was significantly higher in the MH2.5 scaffold than that in the HAp scaffold (p < 0.0001). This study indicated that the MH2.5 scaffold has potential for both osteoinduction and osteoconduction in bone regeneration.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleOsteogenic Properties of Novel Methylsulfonylmethane-Coated Hydroxyapatite Scaffold-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실)-
dc.contributor.googleauthorJeong-Hyun Ryu-
dc.contributor.googleauthorTae-Yun Kang-
dc.contributor.googleauthorHyunjung Shin-
dc.contributor.googleauthorKwang-Mahn Kim-
dc.contributor.googleauthorMin-Ho Hong-
dc.contributor.googleauthorJae-Sung Kwon-
dc.identifier.doi10.3390/ijms21228501-
dc.contributor.localIdA00247-
dc.contributor.localIdA00312-
dc.contributor.localIdA00312-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid33198074-
dc.subject.keywordhydroxyapatite-
dc.subject.keywordmethylsulfonylmethane-
dc.subject.keywordosteoinduction-
dc.subject.keywordscaffold-
dc.contributor.alternativeNameKwon, Jae-Sung-
dc.contributor.affiliatedAuthor권재성-
dc.contributor.affiliatedAuthor김광만-
dc.contributor.affiliatedAuthor김광만-
dc.citation.volume21-
dc.citation.number22-
dc.citation.startPage8501-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(22) : 8501, 2020-11-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers

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