0 29

Cited 0 times in

Clinicopathological Significance of MTUS1 Expression in Patients With Renal Cell Carcinoma

DC FieldValueLanguage
dc.contributor.author신수진-
dc.date.accessioned2020-12-11T07:59:09Z-
dc.date.available2020-12-11T07:59:09Z-
dc.date.issued2020-05-
dc.identifier.issn0250-7005-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180733-
dc.description.abstractBackground/aim: Microtubule-associated tumor suppressor 1 (MTUS1) is a novel tumor suppressor involved in proliferation and migration, and down-regulation of MTUS1 is associated with the poor prognosis of several cancers. We evaluated the clinicopathological significance of MTUS1 expression in renal cell carcinoma (RCC). Patients and methods: We assessed MTUS1 expression by immunohistochemical staining of tissue microarrays from 249 cases of RCC. We analyzed the correlation of MTUS1 expression and clinicopathological characteristics. Additionally, we used public databases and performed bioinformatics analysis. Results: We investigated The Cancer Genome Atlas databases and identified that MTUS1 mRNA expression was significantly lower in RCC tissues than in normal tissues. Loss of MTUS1 expression was correlated with high WHO/ISUP nuclear grade, lymphovascular invasion, renal vein thrombus, and high pT stage in patients with RCC. Although there was no statistically significant correlation between MTUS1 expression and patients' prognosis in our cohort, MTUS1 overexpression was significantly correlated with a favorable prognosis in public data. Conclusion: Loss of MTUS1 expression in RCC might be a potential biomarker for predicting clinical outcome.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherInternational Institute of Anticancer Research-
dc.relation.isPartOfANTICANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCarcinoma, Renal Cell / genetics*-
dc.subject.MESHCarcinoma, Renal Cell / pathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKidney Neoplasms / genetics*-
dc.subject.MESHKidney Neoplasms / pathology-
dc.subject.MESHMale-
dc.subject.MESHPrognosis-
dc.subject.MESHTumor Suppressor Proteins / metabolism*-
dc.titleClinicopathological Significance of MTUS1 Expression in Patients With Renal Cell Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorJongmin Sim-
dc.contributor.googleauthorYoung Chan Wi-
dc.contributor.googleauthorHa Young Park-
dc.contributor.googleauthorSung Yul Park-
dc.contributor.googleauthorYoung Eun Yoon-
dc.contributor.googleauthorSeongsik Bang-
dc.contributor.googleauthorYeseul Kim-
dc.contributor.googleauthorKiseok Jang-
dc.contributor.googleauthorSeong Sam Paik-
dc.contributor.googleauthorSu-Jin Shin-
dc.identifier.doi10.21873/anticanres.14275-
dc.contributor.localIdA04596-
dc.relation.journalcodeJ00188-
dc.identifier.eissn1791-7530-
dc.identifier.pmid32366449-
dc.identifier.urlhttp://ar.iiarjournals.org/content/40/5/2961.long-
dc.subject.keywordMTUS1-
dc.subject.keywordimmunohistochemistry-
dc.subject.keywordprognosis-
dc.subject.keywordpublic data-
dc.subject.keywordrenal cell carcinoma-
dc.contributor.alternativeNameShin, Su Jin-
dc.contributor.affiliatedAuthor신수진-
dc.citation.volume40-
dc.citation.number5-
dc.citation.startPage2961-
dc.citation.endPage2967-
dc.identifier.bibliographicCitationANTICANCER RESEARCH, Vol.40(5) : 2961-2967, 2020-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.