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FGFR1 is associated with c-MYC and proangiogenic molecules in metastatic renal cell carcinoma under anti-angiogenic therapy
DC Field | Value | Language |
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dc.contributor.author | 신수진 | - |
dc.date.accessioned | 2020-12-11T07:58:37Z | - |
dc.date.available | 2020-12-11T07:58:37Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 0309-0167 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180730 | - |
dc.description.abstract | Aims: This study aimed to investigate the clinicopathological significance of FGFR1 and c-MYC expression, particularly in relation to angiogenesis in clear cell renal cell carcinoma (CCRCC). Methods and results: Immunohistochemistry and fluorescence in-situ hybridisation were conducted with tissue microarrays from 91 metastatic CCRCC patients who received VEGF receptor tyrosine kinase inhibitors (VEGFR-TKIs). The expression of angiogenic molecules, FGFR1 and c-MYC, and tumoral vascular density (TVD) and mRNA expression and TVD of 533 CCRCCs in The Cancer Genome Atlas (TCGA) were analysed. FGFR1, pFGFR1 and c-MYC expression was observed in 29.1, 74.4 and 30.8% of tumours, respectively. FGFR1high was an independent worse prognostic factor for overall (HR = 1.871, P = 0.032) and progression-free (HR = 1.976, P = 0.016) survival. FGFR1high was significantly related to VEGFR-TKI responsiveness (P = 0.011). The presence of FGFR1high /c-MYChigh showed a positive correlation with proangiogenic markers, including VEGF (P = 0.018) and HIF-1α (P < 0.0001). FGFR1high /c-MYChigh tumours showed higher TVDs together with higher VEGFR2 and PDGFR-β expression (both P < 0.0001). FGFR1 and c-MYC expression was also positively correlated with the expression of hypoxia-related and proangiogenic-related genes in the TCGA data. Conclusions: FGFR1 and c-MYC may be involved in tumour angiogenesis and FGFR1 may represent a promising therapeutic target in metastatic CCRCC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Scientific Publications | - |
dc.relation.isPartOf | HISTOPATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | FGFR1 is associated with c-MYC and proangiogenic molecules in metastatic renal cell carcinoma under anti-angiogenic therapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Jee Young Park 1 , Pil-Jong Kim 2 , Su-Jin Shin 3 , Jae-Lyun Lee 4 , Yong Mee Cho 5 , Heounjeong Go 5 | - |
dc.identifier.doi | 10.1111/his.14076 | - |
dc.contributor.localId | A04596 | - |
dc.relation.journalcode | J00994 | - |
dc.identifier.eissn | 1365-2559 | - |
dc.identifier.pmid | 31990416 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1111/his.14076 | - |
dc.subject.keyword | angiogenesis | - |
dc.subject.keyword | c-MYC | - |
dc.subject.keyword | fibroblast growth factor receptor 1 | - |
dc.subject.keyword | metastatic clear cell renal cell carcinoma | - |
dc.contributor.alternativeName | Shin, Su Jin | - |
dc.contributor.affiliatedAuthor | 신수진 | - |
dc.citation.volume | 76 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 838 | - |
dc.citation.endPage | 851 | - |
dc.identifier.bibliographicCitation | HISTOPATHOLOGY, Vol.76(6) : 838-851, 2020-05 | - |
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