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Synergistic anticancer activity of sorafenib, paclitaxel, and radiation therapy on anaplastic thyroid cancer in vitro and in vivo

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dc.contributor.author김석모-
dc.contributor.author김수영-
dc.contributor.author박정수-
dc.contributor.author이용상-
dc.contributor.author장항석-
dc.contributor.author장호진-
dc.date.accessioned2020-12-11T07:55:39Z-
dc.date.available2020-12-11T07:55:39Z-
dc.date.issued2020-12-
dc.identifier.issn1043-3074-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180713-
dc.description.abstractBackground: This study aimed to investigate the antitumor activity of paclitaxel with radiation and sorafenib in anaplastic thyroid cancer (ATC) cells in vitro and in vivo. Methods: The 8505C ATC cell line was exposed to radiation, sorafenib, and paclitaxel each or in combination. The effects of combined treatment on the cell cycle and intracellular signaling pathways were assessed using flow cytometry and western blot analysis. An ATC cell line xenograft model was used to examine antitumor activity in vivo. Results: Radiation, paclitaxel plus sorafenib synergistically decreased cell viability in ATC cells and significantly increased apoptotic cell death. The combination of paclitaxel, sorafenib with radiation reduced the antiapoptotic factor in ATC. This combination therapy significantly reduced the tumor volume and increased survival in the ATC xenograft model. Conclusions: These results suggest that the combination of radiation and paclitaxel plus sorafenib has significant anticancer activity in preclinical models.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherJohn Wiley And Sons-
dc.relation.isPartOfHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSynergistic anticancer activity of sorafenib, paclitaxel, and radiation therapy on anaplastic thyroid cancer in vitro and in vivo-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorSoo Young Kim-
dc.contributor.googleauthorSeok-Mo Kim-
dc.contributor.googleauthorHojin Chang-
dc.contributor.googleauthorHang-Seok Chang-
dc.contributor.googleauthorCheong Soo Park-
dc.contributor.googleauthorYong Sang Lee-
dc.identifier.doi10.1002/hed.26431-
dc.contributor.localIdA00542-
dc.contributor.localIdA04725-
dc.contributor.localIdA01646-
dc.contributor.localIdA02978-
dc.contributor.localIdA03488-
dc.contributor.localIdA03496-
dc.relation.journalcodeJ00963-
dc.identifier.eissn1097-0347-
dc.identifier.pmid32896015-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/hed.26431-
dc.subject.keywordanaplastic thyroid cancer-
dc.subject.keywordmultimodality treatment-
dc.subject.keywordpaclitaxel-
dc.subject.keywordradiation-
dc.subject.keywordsorafenib-
dc.contributor.alternativeNameKim, Seok Mo-
dc.contributor.affiliatedAuthor김석모-
dc.contributor.affiliatedAuthor김수영-
dc.contributor.affiliatedAuthor박정수-
dc.contributor.affiliatedAuthor이용상-
dc.contributor.affiliatedAuthor장항석-
dc.contributor.affiliatedAuthor장호진-
dc.citation.volume42-
dc.citation.number12-
dc.citation.startPage3678-
dc.citation.endPage3684-
dc.identifier.bibliographicCitationHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.42(12) : 3678-3684, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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