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Ventromedial hypothalamic primary cilia control energy and skeletal homeostasis

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dc.contributor.author김기우-
dc.contributor.author문석준-
dc.contributor.author신동민-
dc.date.accessioned2020-12-11T07:54:28Z-
dc.date.available2020-12-11T07:54:28Z-
dc.date.issued2020-10-
dc.identifier.issn0021-9738-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180705-
dc.description.abstractDysfunction of primary cilia is related to dyshomeostasis, leading to a wide range of disorders. The ventromedial hypothalamus (VMH) is known to regulate several homeostatic processes, but those modulated specifically by VMH-primary cilia are not yet known. In this study, we identify VMH-primary cilia as an important organelle that maintains energy and skeletal homeostasis by modulating the autonomic nervous system. We established loss-of-function models of primary cilia in the VMH by either targeting IFT88 (IFT88 KOSF-1) using steroidogenic factor 1-Cre (SF1-Cre) or injecting an adeno-associated virus Cre (AAV-Cre) directly into the VMH. Functional impairments of VMH-primary cilia were linked to decreased sympathetic activation and central leptin resistance, which led to marked obesity and bone density accrual. Obesity was caused by hyperphagia, decreased energy expenditure, and blunted brown fat function, as well as associated with insulin and leptin resistance. The effect of bone density accrual was independent from obesity, as it was caused by the decreased sympathetic tone resulting in increased osteoblastic and decreased osteoclastic activities in the IFT88 KOSF-1 and VMH-primary cilia knock-down mice. Overall, our current study identifies VMH-primary cilia as a critical hypothalamic organelle that maintains energy and skeletal homeostasis.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Society for Clinical Investigation-
dc.relation.isPartOfJOURNAL OF CLINICAL INVESTIGATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleVentromedial hypothalamic primary cilia control energy and skeletal homeostasis-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorJi Su Sun-
dc.contributor.googleauthorDong Joo Yang-
dc.contributor.googleauthorAnn W Kinyua-
dc.contributor.googleauthorSeul Gi Yoon-
dc.contributor.googleauthorJe Kyung Seong-
dc.contributor.googleauthorJuwon Kim-
dc.contributor.googleauthorSeok Jun Moon-
dc.contributor.googleauthorDong Min Shin-
dc.contributor.googleauthorYun-Hee Choi-
dc.contributor.googleauthorKi Woo Kim-
dc.identifier.doi10.1172/JCI138107-
dc.contributor.localIdA05301-
dc.contributor.localIdA01358-
dc.contributor.localIdA01358-
dc.contributor.localIdA02091-
dc.contributor.localIdA02091-
dc.relation.journalcodeJ01322-
dc.identifier.eissn1558-8238-
dc.identifier.pmid33021968-
dc.subject.keywordEndocrinology-
dc.subject.keywordHomeostasis-
dc.subject.keywordLeptin-
dc.subject.keywordMetabolism-
dc.subject.keywordObesity-
dc.contributor.alternativeNamekim, KiWoo-
dc.contributor.affiliatedAuthor김기우-
dc.contributor.affiliatedAuthor문석준-
dc.contributor.affiliatedAuthor문석준-
dc.contributor.affiliatedAuthor신동민-
dc.contributor.affiliatedAuthor신동민-
dc.citation.startPageEpub.-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL INVESTIGATION, : Epub., 2020-10-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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